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Human studies have investigated the hypothesised association between SV40 and various cancers, but the results have so far been contradicting. The aim of the present study was to examine Norwegian cancer incidence data to assess a possible association between birth cohorts assumed to have been subjected to the vaccine and the incidence rate of lymphoproliferative disorders (excluding Hodgkin's lymphoma), further subdivided into non\u2010Hodgkin's lymphoma (NHL), lymphocytic leukemia and plasma cell neoplasms. Between 1953 and 1997, the incidence rate of lymphoproliferative diseases combined increased about 3\u2010fold in both males and females. Subgroup analysis showed that this increase was largely attributable to NHL. Age\u2013period\u2013cohort modelling of the subgroups, as well as of all groups combined, showed that the cohort effect was more prominent than the period effect. However, the variations in incidence patterns across the birth cohorts did not fit with the trends that would be expected if a SV40 contaminated vaccine did play a causative role. Thus, our data do not support the hypothesis of an association between the vaccine and any subgroup of lymphoproliferative diseases. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21603","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T23:51:47Z","timestamp":1132185107000},"page":"2035-2039","source":"Crossref","is-referenced-by-count":11,"title":["Is there an association between SV40 contaminated polio vaccine and lymphoproliferative disorders? An age\u2013period\u2013cohort analysis on Norwegian data from 1953 to 1997"],"prefix":"10.1002","volume":"118","author":[{"given":"Guri Olsen","family":"Thu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling Yuan","family":"Hem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svein","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarle","family":"Norstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"N\u00f8kleby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Grotmol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.703"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10403"},{"key":"e_1_2_5_4_2","first-page":"621","article-title":"Rising incidence of Non\u2010Hodgkin lymphoma in Spain: analysis of period of diagnosis and cohort effects","volume":"7","author":"Poll\u00e1n M","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13868-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00401-8"},{"key":"e_1_2_5_7_2","first-page":"5927","article-title":"[Infectious causes of non\u2010Hodgkin lymphomas]","volume":"164","author":"Munksgaard L","year":"2002","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_5_8_2","volume-title":"Cancer in Norway","author":"Cancer Registry of Norway","year":"2002"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-105-26128"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.2.119"},{"key":"e_1_2_5_11_2","unstructured":"www.fhi.no\/vaksine\/barnevaksinasjonsprogrammet"},{"issue":"3","key":"e_1_2_5_12_2","first-page":"164","article-title":"[Immunity to poliomyelitis. 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