{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:56:10Z","timestamp":1697345770742},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,11,14]],"date-time":"2005-11-14T00:00:00Z","timestamp":1131926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gastrointestinal stromal tumors are mesenchymal tumors arising in the stomach and small bowel and more rarely in the rectum, esophagus, peritoneum and retroperitoneum. These tumors are characterized by <jats:italic>KIT<\/jats:italic> or <jats:italic>PDGFRA<\/jats:italic> mutations. <jats:italic>KIT<\/jats:italic> mutations are all in frame and lead to constitutive tyrosine kinase domain activation without ligand binding. Mutations concern four exons (9, 11, 13 and 17) but mainly exon 11. We report a new mutation in exon 9, since only AY 502\u2013503 duplication\/insertion, FAF 506 insertion and P456S substitution have been previously reported. This mutation consists of a large deletion of 43 nucleotides and an insertion of 25 nucleotides. More surprisingly, the sequence inserted corresponds to the complementary sequence of the wild allele but in the opposite sense. To our knowledge, this mutation has never been previously described. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21607","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T23:55:27Z","timestamp":1132185327000},"page":"2089-2091","source":"Crossref","is-referenced-by-count":13,"title":["Detection of a new mutation in <i>KIT<\/i> exon 9 in a gastrointestinal stromal tumor"],"prefix":"10.1002","volume":"118","author":[{"given":"Isabelle","family":"Hostein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Longy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Gastaldello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga\u00eblle","family":"Geneste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Coindre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,14]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.140"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079666"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1309\/4E6UYBY62N2FCA6N"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2004.23.777"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64623-8"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64946-2"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20110"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH818>3.0.CO;2-E"},{"key":"e_1_2_2_10_2","first-page":"3329","article-title":"Association of KIT exon 9 mutations with non\u2010gastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors","volume":"9","author":"Antonescu CR","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.190"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20377"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60533-8"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:07:27Z","timestamp":1697173647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,14]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,4,15]]}},"alternative-id":["10.1002\/ijc.21607"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21607","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,14]]}}}