{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:33:03Z","timestamp":1791221583927,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,27]],"date-time":"2005-12-27T00:00:00Z","timestamp":1135641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastasis to the bone is a major clinical complication in patients with prostate cancer (PC). However, therapeutic options for treatment of PC bone metastasis are limited. Gelatinases are members of the matrix metalloproteinase (MMP) family and have been shown to play a key role in PC metastasis. Herein, we investigated the effect of SB\u20103CT, a covalent mechanism\u2010based MMP inhibitor with high selectivity for gelatinases, in an experimental model of PC bone metastases. Intraperitoneal (i.p.) treatment with SB\u20103CT (50 mg\/kg) inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice, as demonstrated by histomorphometry and Ki\u201067 immunohistochemistry. The anti\u2010osteolytic effect of SB\u20103CT was confirmed by radiographic images. Treatment with SB\u20103CT also reduced intratumoral vascular density and bone degradation in the PC3 bone tumors. <jats:italic>A<\/jats:italic> direct inhibition of bone marrow endothelial cell invasion and tubule formation in Matrigel by SB\u20103CT <jats:italic>in vitro<\/jats:italic> was also demonstrated. The use of the highly selective gelatinase inhibitors holds the promise of effective intervention of metastases of PC to the bone. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21645","type":"journal-article","created":{"date-parts":[[2005,12,27]],"date-time":"2005-12-27T22:17:37Z","timestamp":1135721857000},"page":"2721-2726","source":"Crossref","is-referenced-by-count":78,"title":["Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism\u2010based selective gelatinase inhibitor"],"prefix":"10.1002","volume":"118","author":[{"given":"R. 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