{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:58:38Z","timestamp":1773280718789,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,12,27]],"date-time":"2005-12-27T00:00:00Z","timestamp":1135641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biliary tract cancers, encompassing cancers of the gallbladder, extrahepatic bile duct and ampulla of Vater, are rare but highly fatal malignancies. Other than gallstones, little is known about the risk factors for biliary tract cancers. Endogenous estrogens are thought to play a role in the etiology of gallstones and gallbladder cancer, since both conditions predominate in females and are associated with parity and obesity. In view of reports linking the <jats:italic>CYP17<\/jats:italic> MspA1 polymorphism to high circulating levels of estrogens and a predisposition to other hormonally related cancers, we examined the relationship between <jats:italic>CYP17<\/jats:italic> MspA1 variants and risk of biliary disease in a population\u2010based case\u2010control study in Shanghai. The study included 446 cancer cases (254 gallbladder, 139 extrahepatic bile duct, 53 ampullary cancers), 929 biliary stone cases (691 gallbladder, 238 bile duct) and 818 population controls. Genomic DNA from peripheral blood lymphocytes was used for genotyping. Relative to those with the A2\/A2 genotype, A1 carriers (A1\/A1 and A1\/A2 genotypes) had an increased risk of gallbladder cancer (odds ratio (OR) = 1.5, 95% confidence interval (CI) = 1.1\u20132.1). In addition, women with the A1 allele and high parity (\u22653) had a 3\u2010fold risk of gallbladder cancer (OR = 3.3, 95% CI = 1.6\u20136.9), compared to those with the A2\/A2 genotype and lower parity, with the highest risk seen for those also having biliary stones (OR = 4.6, 95% CI = 1.8\u201311.7, <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = 0.04). The A1 allele was not associated with a higher risk of gallstones except among those with body mass index (BMI) greater than 25 kg\/m<jats:sup>2<\/jats:sup> (OR = 3.1, 95% CI = 2.0\u20134.8, <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = 0.02) and among those with a history of diabetes (OR = 2.5, 95% CI = 1.4\u20134.3, <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub> = 0.09). No clear relation was seen between the <jats:italic>CYP17<\/jats:italic> polymorphism and cancers of the bile duct or ampulla of Vater. The association of the <jats:italic>CYP17<\/jats:italic> MspA1 polymorphism with an increased risk of gallbladder cancer, as well as biliary stones among overweight and diabetic individuals, suggests an interplay between genetic and hormonal risk factors in gallbladder disease. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21708","type":"journal-article","created":{"date-parts":[[2005,12,27]],"date-time":"2005-12-27T22:16:51Z","timestamp":1135721811000},"page":"2847-2853","source":"Crossref","is-referenced-by-count":21,"title":["<i>CYP17<\/i> MspA1 polymorphism and risk of biliary tract cancers and gallstones: A population\u2010based study in Shanghai, China"],"prefix":"10.1002","volume":"118","author":[{"given":"Lifang","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00edqun Lilly","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori 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