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To verify whether HLA class II DQB1 polymorphism is related to cervical cancer in Chinese population, HLA\u2010DQB typing was carried out by PCR\u2010SBT for 258 patients with cervical cancer and 284 healthy controls, and the allele frequencies were calculated. In this study, HLA\u2010DQB1*060101 and DQB1*0602 alleles were significantly higher in the HPV16 infected patients with cervical cancer compared with healthy controls (\u03c7<jats:sup>2<\/jats:sup> = 31.7452, <jats:italic>p<\/jats:italic> &lt; 0.0001; \u03c7<jats:sup>2<\/jats:sup> = 12.7838, <jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub> = 0.0066), but DQB1*050201 allele was significantly lower (\u03c7<jats:sup>2<\/jats:sup> = 26.2187, <jats:italic>p<\/jats:italic> &lt; 0.0001). This result indicates that HLA\u2010DQB1*060101 and DQB1*0602 may confer susceptibility to cervical cancer, and DQB1*050201 may contribute to the resistance to the development of cervical cancer among Chinese women. Sequence analysis reveals that DQB1*060101 allele encodes Leu at position 9 and Asp at position 37, unique to the susceptibility to cervical cancer, whereas the other DQB1 alleles encode Phe or Tyr and Ile or Tyr at the same two positions, respectively. This finding implies that polymorphic amino acids at the putative antigen binding residues 9 and 37 of HLA\u2010DQB1 alleles may play an important role in the development of cervical cancer. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21746","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T22:20:57Z","timestamp":1137709257000},"page":"3006-3011","source":"Crossref","is-referenced-by-count":24,"title":["Polymorphic amino acids at codons 9 and 37 of HLA\u2010DQB1 alleles may confer susceptibility to cervical cancer among Chinese women"],"prefix":"10.1002","volume":"118","author":[{"given":"Yuping","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.90010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20048"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/340824"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1520"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0595-464"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh201"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/352723a0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570411"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401564"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.1998.00108.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960904)67:5<595::AID-IJC1>3.0.CO;2-P"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00127-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0294-157"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980330)76:1<19::AID-IJC4>3.0.CO;2-0"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1412"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00191-0"},{"key":"e_1_2_6_21_2","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/JCM.37.3.796-797.1999","article-title":"Comparative evaluation of first\u2010 and second\u2010generation Digene Hybrid Capture assays for detection of human papillomaviruses associated with high or intermediate risk for cervical cancer","volume":"37","author":"Poljak M","year":"1999","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/jcm.34.3.745-747.1996","article-title":"Comprehensive study of several general and type specific primer pairs for detection of human papillomavirus DNA by PCR in paraffin\u2010embedded cervical carcinomas","volume":"34","author":"Baay MF","year":"1996","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_23_2","first-page":"477","article-title":"A comparison between real\u2010time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation","volume":"12","author":"Gravitt PE","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_24_2","unstructured":"Van Der ZwanA GriffithB RozemullerE WilliamsT TilanusMGJ. 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