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We used carbohydrate array technology to compare serum antibody (IgG and IgM) levels against 37 different carbohydrates between classical Hodgkin's lymphoma (cHL) patients and age\/sex\u2010matched healthy controls. Serum IgM levels measured by ELISA against 2 of the 5 carbohydrates identified using this technique, L\u2010\u03b1\u2010arabinose (L\u2010Araf) and \u03b1\u2010<jats:italic>N<\/jats:italic>\u2010acetylgalactosamine (GalNAc(\u03b1)), were higher (F values of 11.30 and 18.27, respectively) in a cohort of cHL patients (<jats:italic>n<\/jats:italic> = 16) than either diffuse large B\u2010cell lymphoma patients (<jats:italic>n<\/jats:italic> = 18) or control sera (<jats:italic>n<\/jats:italic> = 12). Higher anti\u2010L\u2010Araf IgM levels in cHL patients were associated with cytosine arabinoside treatment (<jats:italic>p<\/jats:italic> &lt; 0.05). The GalNAc(\u03b1) glycotope, Tn, was found to be heterogeneously expressed in the Reed\u2010Sternberg cells of 9\/20 (45%) cHL cases, but not in malignant cells of 25 cases of lymphocyte\u2010predominant HL or another 21 hematological disorders (291 cases) examined immunohistochemically. Tn was expressed in 41\/238 (17%) classical HL cases present on a tissue microarray. Expression was associated with CD79a and LMP1 expression and negatively with p27<jats:sup>KIP1<\/jats:sup> expression (<jats:italic>p<\/jats:italic> &lt; 0.05). Kaplan\u2010Meier survival analysis revealed a trend towards improved relapse\u2010free survival with Tn expression although this was not statistically significant (<jats:italic>p<\/jats:italic> = 0.271). We suggest that this technique could provide a powerful tool for identifying novel carbohydrates in other cancers. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21762","type":"journal-article","created":{"date-parts":[[2006,1,4]],"date-time":"2006-01-04T21:51:23Z","timestamp":1136411483000},"page":"3161-3166","source":"Crossref","is-referenced-by-count":44,"title":["Cancer\u2010associated carbohydrate identification in Hodgkin's lymphoma by carbohydrate array profiling"],"prefix":"10.1002","volume":"118","author":[{"given":"Charles H.","family":"Lawrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Marafioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian S.R.","family":"Hatton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Dirnhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Roncador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Went","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandar","family":"Tzankov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano A.","family":"Pileri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Pulford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H.","family":"Banham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"143","article-title":"The involvement of Helix pomatia lectin (HPA) binding to N\u2010acteylgalactosamine glycans in cancer progression","volume":"15","author":"Brooks SA","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1981.tb06300.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.08.031"},{"key":"e_1_2_5_5_2","first-page":"237","volume-title":"World Health Organisation (WHO) classification of tumours\u2010pathology & genetics\u2010tumours of haematopoietic and lymphoid tissues","author":"Stein H","year":"2001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwg091"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwh022"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1385\/0896032795"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1279"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1487"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(99)00167-1"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(03)00054-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2003.09.002"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0471-y"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6215(98)00070-6"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970926)73:1<50::AID-IJC9>3.0.CO;2-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02484401"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050144"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02813.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000064026"},{"key":"e_1_2_5_21_2","first-page":"1577","article-title":"Biochemical characterization of soluble Tn glycoproteins from malignant effusions of patients with carcinomas","volume":"10","author":"Freire T","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91882-D"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000093627.51090.3F"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890515)63:10<2030::AID-CNCR2820631027>3.0.CO;2-P"},{"key":"e_1_2_5_25_2","first-page":"370","article-title":"Lectin receptors as markers of lymphoid cells. 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