{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:52:54Z","timestamp":1790898774843,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T00:00:00Z","timestamp":1138665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer in developed countries. Little is known about its causes, although its early age at diagnosis has focused interest on maternal and perinatal factors. We have previously observed a protective effect of maternal folate supplementation during pregnancy against ALL, and a number of studies have reported protective effects of some common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene. One study has suggested that the effect of MTHFR polymorphisms on risk of ALL may depend on folate status. This study aimed to look for evidence of an interaction between maternal folate supplementation and child's genotype among the cases from our previous study. Bone marrow specimens from 82 of 83 case children were available. DNA was extracted and genotyped for <jats:italic>MTHFR C677T<\/jats:italic> and <jats:italic>A1298C<\/jats:italic> using standard techniques. We used a case\u2010only analysis to estimate the case\u2010only odds ratio (COR) for MTHFR genotype and folate supplementation in association with ALL. None of the CORs indicated a significant departure from a multiplicative model. Adjustment for sex, age or genotype at the other locus had little effect on the results. Other studies of this gene and environment interaction in ALL and other cancers have produced contradictory results, perhaps because of varying definitions of folate exposure. Further research into the interaction of folate intake and genotype in causing ALL and other cancers is needed. We are specifically studying it in an Australian national case\u2010control study of genetic and environmental causes of ALL. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21803","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T22:16:45Z","timestamp":1138745805000},"page":"229-232","source":"Crossref","is-referenced-by-count":23,"title":["Is there a folate\u2010related gene\u2010environment interaction in the etiology of childhood acute lymphoblastic leukemia?"],"prefix":"10.1002","volume":"119","author":[{"given":"Elizabeth","family":"Milne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas H.","family":"de Klerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van Bockxmeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula R.","family":"Kees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith R.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,17]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"ParkinDM KramarovaE DraperGJ.International incidence of childhood cancer vol.II. IARC Scientific Publication No. 144 1998."},{"key":"e_1_2_5_3_2","volume-title":"Epidemiology of childhood cancer","author":"Little J","year":"1999"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06959-8"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03140.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-1794"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061408298"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12810"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1182\/blood.V89.11.4161","article-title":"Homozygous deletion of the p16\/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome","volume":"89","author":"Kees UR","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008915"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970815)16:15<1731::AID-SIM595>3.0.CO;2-S"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/301825"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.973"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.5.478"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.1.21"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000010291"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf322"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mph.0000177513.81465.94"},{"key":"e_1_2_5_19_2","first-page":"139","article-title":"Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population","volume":"89","author":"Chiusolo P","year":"2004","journal-title":"Haematologia (Budap)"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062066299"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3290"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2000.tb01863.x"},{"issue":"2","key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"560S","DOI":"10.1093\/jn\/129.2.560S","article-title":"MTHFR polymorphism, methyl\u2010replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene\u2010environment interactions in colorectal tumorigenesis","volume":"129","author":"Chen J","year":"1999","journal-title":"J Nutr"},{"key":"e_1_2_5_24_2","first-page":"1098","article-title":"Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer","volume":"57","author":"Ma J","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_5_25_2","first-page":"513","article-title":"Methylenetetrahydrofolate reductase, diet, and risk of colon cancer","volume":"8","author":"Slattery ML","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015057614870"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2630"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.01.026"},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1158\/1055-9965.2071.13.12","article-title":"MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study","volume":"13","author":"Le Marchand L","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0273"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T20:34:29Z","timestamp":1695933269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,17]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1002\/ijc.21803"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21803","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,17]]}}}