{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:39:54Z","timestamp":1780475994737,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T00:00:00Z","timestamp":1139788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to characterize the familial risk of colon and rectal cancer using 2 population\u2010based registries in Iceland, the Icelandic Cancer Registry and a genealogy database. The standardized incidence ratio (SIR) was used to estimate the risk among relatives of colorectal cancer index cases diagnosed in Iceland over a 46\u2010year period (1955\u20132000). The 2,770 colorectal cancer patients had 23,272 first\u2010degree relatives. Among first\u2010degree relatives, there was an increased risk of both colon (SIR 1.47, 95% confidence interval (CI) 1.34\u20131.62) and rectal cancer (SIR 1.24, 95% CI 1.04\u20131.47). An increased risk of colon cancer was observed among siblings of colon cancer patients (SIR 2.03, 95% CI 1.76\u20132.33), whereas no such increase was observed for parents or offspring. Furthermore, the risk of rectal cancer was only increased among brothers (SIR 2.46 95% CI 1.46\u20133.89) of rectal cancer patients and not among their sisters (SIR 1.0 95% CI 0.40\u20132.06). The added risk of colon cancer among first\u2010degree relatives was independent of site of colon cancer in the proband. Our results confirm that family history of colorectal cancer is a risk factor for the disease. However, family history has a different association with colon cancer than with rectal cancer, suggesting that the 2 cancer types may have different etiologic factors. Our results have implications for colon and rectal cancer screening programs. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21835","type":"journal-article","created":{"date-parts":[[2006,2,13]],"date-time":"2006-02-13T22:47:05Z","timestamp":1139870825000},"page":"304-308","source":"Crossref","is-referenced-by-count":16,"title":["Familial risk of colon and rectal cancer in Iceland: Evidence for different etiologic factors?"],"prefix":"10.1002","volume":"119","author":[{"given":"Tryggvi","family":"Stefansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pall H.","family":"Moller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridbjorn","family":"Sigurdsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirikur","family":"Steingrimsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarki J\u00f3nsson","family":"Eldon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10332"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197107)28:1<14::AID-CNCR2820280105>3.0.CO;2-I"},{"key":"e_1_2_6_4_2","first-page":"43","article-title":"Studies of Japanese migrants. 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