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The aim of this study was to employ MRI means to measure the microvascular perfusion parameters of orthotopic nonsmall cell lung cancer, using the experimental rat model. Anatomical and dynamic contrast\u2010enhanced lung images were acquired at high spatial resolution, and registered and analyzed, pixel by pixel and globally, by means of a model\u2010based algorithm. The MRI output yielded color\u2010coded parametric images of the influx and efflux transcapillary transfer constants that indicated rapid microvascular perfusion. The transfer constants were about 1 order of magnitude higher than those found in other tumors or in nonorthotopic lung cancer, with the influx constant median value of 0.42 min<jats:sup>\u22121<\/jats:sup> and the efflux constant median value of 1.61 min<jats:sup>\u22121<\/jats:sup>. The rapid perfusion was in accord with the immunostaining of the capillaries, which suggested the tumor exploitation of the existing alveolar vessels. The results showed that high resolution, dynamic, contrast\u2010enhanced MRI is an effective tool for the quantitative measurement of spatial and temporal changes in lung cancer perfusion and vasculature. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21857","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T23:57:04Z","timestamp":1139529424000},"page":"365-372","source":"Crossref","is-referenced-by-count":3,"title":["Vascular perfusion of human lung cancer in a rat orthotopic model using dynamic contrast\u2010enhanced magnetic resonance 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