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Here, we report that VEGFR\u20101 is expressed on a panel of 16 human breast tumor cell lines, and the vasculature and the tumor cell compartment of a subset of breast carcinoma lesions, and that selective signaling through VEGFR\u20101 on breast cancer cells supports tumor growth through downstream activation of the p44\/42 mitogen\u2010activated protein kinase (MAPK) or Akt pathways. Ligand\u2010stimulated proliferation of breast tumor cells was inhibited by specific blockade with an anti\u2010VEGFR\u20101 neutralizing monoclonal antibody. Treatment with anti\u2010VEGFR\u20101 mAb significantly suppressed the growth of DU4475, MCF\u20107, BT\u2010474 and MDA\u2010MB\u2010231 breast xenografts in athymic mice. Histological examination of anti\u2010VEGFR\u20101 mAb treated tumor xenografts showed a significant reduction of activation of the p44\/42 MAPK or Akt pathways in tumor cells resulting in an increase in tumor cell apoptosis. Importantly, cotreatment with mAbs targeting human VEGFR\u20101 on tumor cells and murine VEGFR\u20101 on vasculature led to more potent growth inhibition of breast tumor xenografts. The results suggest that VEGF receptors may not only modulate angiogenesis, but also directly influence the growth of VEGF receptor expressing tumors. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21865","type":"journal-article","created":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T21:18:31Z","timestamp":1146604711000},"page":"1519-1529","source":"Crossref","is-referenced-by-count":157,"title":["The vascular endothelial growth factor receptor (VEGFR\u20101) supports growth and survival of human breast carcinoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Yan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea 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