{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:46:41Z","timestamp":1778755601160,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T00:00:00Z","timestamp":1143590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent research suggests that cutaneous melanomas may arise through 2 distinct pathways, characterized by chronic sun exposure on one hand and nevus\u2010prone phenotype of the host on the other. Two histological characteristics of melanoma consistent with these divergent origins are dermal elastosis in adjacent skin and neval remnants contiguous with the tumor, respectively. To further explore causal heterogeneity in melanoma, we compared sun exposure histories and phenotypic characteristics among a population\u2010based sample of patients newly diagnosed with cutaneous melanoma with and without contiguous neval remnants or dermal elastosis. Tissue blocks were obtained for 141 patients: 53 with superficial spreading melanoma (SSM) of the back, 42 with SSM of head and neck (H &amp; N), and 39 and 7 with lentigo maligna\/lentigo maligna melanoma (LM\/LMM) of the H &amp; N and back, respectively. Melanomas of the H &amp; N were less likely than those on back to have neval remnants (adjusted OR 0.6, 95% CI 0.3\u20131.4), but were significantly more likely to have dermal elastosis (adjusted OR 9.3, 95% CI 3.5\u201325). In site\u2010specific analyses, we found that H &amp; N melanomas with neval remnants were more likely than those without neval remnants to arise in people with more than 60 nevi (adjusted OR 2.1, 95% CI 0.3\u201314.3), but were less likely to arise in those with more than 20 actinic keratoses. Less marked associations were observed for melanomas of the back. High levels of sun exposure strongly predicted dermal elastosis for H &amp; N melanomas (OR 22.5, 95% CI 2.1\u2013245), but not for melanomas of the back (OR 2.1, 95% CI 0.4\u201311). We conclude that melanomas with different histologic characteristics have different risk factor profiles, particularly on the head and neck. These data accord with the hypothesis that melanomas arise through different causal pathways. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21907","type":"journal-article","created":{"date-parts":[[2006,3,29]],"date-time":"2006-03-29T23:17:48Z","timestamp":1143674268000},"page":"636-642","source":"Crossref","is-referenced-by-count":34,"title":["Sun exposure and host phenotype as predictors of cutaneous melanoma associated with neval remnants or dermal elastosis"],"prefix":"10.1002","volume":"119","author":[{"given":"Eva Y.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Watt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Celia","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e8le C.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,8]]},"reference":[{"key":"e_1_2_6_2_2","series-title":"Prevention of skin cancer","author":"Armstrong BK","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(01)00198-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg123"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.806"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(80)80069-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80030-2"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530210"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052747"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<288::AID-CNCR13>3.0.CO;2-S"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880701)62:1<163::AID-CNCR2820620126>3.0.CO;2-N"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90294-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1990.tb00656.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70253-X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70436-6"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.12.1620"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200206000-00011"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0097"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199904000-00012"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90282-1"},{"key":"e_1_2_6_21_2","first-page":"75","article-title":"Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types","volume":"73","author":"Holman CD","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_22_2","first-page":"5036","article-title":"Incidence of cutaneous melanoma in the United States by histology with special reference to the face","volume":"48","author":"Newell GR","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_6_23_2","first-page":"361","article-title":"A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage I. 6. The relation of dermal solar elastosis to sex, age and survival of the patient and to localization, histological type and level of invasion of the tumour","volume":"87","author":"Larsen TE","year":"1979","journal-title":"Acta Pathol Microbiol Scand [A]"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028709103888"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.6.734"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028309061399"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028009060079"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21907","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T18:58:59Z","timestamp":1696877939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,8]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1002\/ijc.21907"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21907","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,8]]}}}