{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:07:48Z","timestamp":1775027268834,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T00:00:00Z","timestamp":1146009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iodine is concentrated by the gastric mucosa, where it may act as an antioxidant. Therefore, iodine deficiency, and its sequelae goiter, may be associated with an increased risk of gastric cancer. We examined the association between self\u2010reported goiter and upper gastrointestinal cancer in a Chinese cohort of 29,584 adults. Using multivariate adjusted Cox models, we found goiter associated with a significantly increased risk of gastric noncardia adenocarcinoma, HR (95% CI) 2.04 (1.01, 4.11) and nonsignificantly with gastric cardia adenocarcinoma, HR (95% CI) 1.45 (0.91, 2.30). We also found a borderline, insignificant increased risk of esophageal squamous cell carcinoma, HR (95% CI) 1.37 (0.97, 1.94). Our findings are consistent with the hypothesis that iodine deficiency is associated with an increased risk of gastric cancer. Published 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.21993","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T21:49:48Z","timestamp":1146088188000},"page":"1508-1510","source":"Crossref","is-referenced-by-count":18,"title":["Self\u2010reported goiter is associated with a significantly increased risk of gastric noncardia adenocarcinoma in a large population\u2010based Chinese cohort"],"prefix":"10.1002","volume":"119","author":[{"given":"Christian C.","family":"Abnet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Hu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farin","family":"Kamangar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Di","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Song","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Joseph F.","family":"Fraumeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanford M.","family":"Dawsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,26]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00486-7"},{"key":"e_1_2_5_3_2","first-page":"11","article-title":"Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach","volume":"4","author":"Venturi S","year":"2000","journal-title":"Adv Clin Path"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000503300210"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.26719\/2004.10.6.921","article-title":"Urinary iodine\/creatinine ratio in patients with stomach cancer in Urmia, Islamic Republic of Iran","volume":"10","author":"Behrouzian R","year":"2004","journal-title":"East Mediterr Health J"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2005.101"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.1.181"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc703"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.10.070190.000321"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.18.1483"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/1047-2797(93)90078-I"},{"key":"e_1_2_5_12_2","first-page":"176","article-title":"Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China","volume":"113","author":"Tran GD","year":"2004","journal-title":"Int J Cancer"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.3.226"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.21993","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.21993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T19:50:17Z","timestamp":1695930617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.21993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,26]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,9,15]]}},"alternative-id":["10.1002\/ijc.21993"],"URL":"https:\/\/doi.org\/10.1002\/ijc.21993","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,26]]}}}