{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T05:40:10Z","timestamp":1697002810897},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Members of the <jats:italic>BCL\u20102<\/jats:italic> gene family are well known for their role in the pathogenesis of B\u2010cell lymphomas in humans and in mouse models. A recent report that knockout mice deficient for the proapoptotic BCL\u20102 family member gene <jats:italic>BAD<\/jats:italic> frequently develop B\u2010cell lymphomas prompted us to analyze a large collection of human B\u2010cell lymphomas for inactivating mutations in the <jats:italic>BAD<\/jats:italic> gene. All 3 exons of the <jats:italic>BAD<\/jats:italic> gene were amplified and directly sequenced. The 81 lymphomas analyzed included 16 cases of B\u2010cell chronic lymphocytic leukemia, 11 mantle\u2010cell lymphomas, 10 follicular lymphomas, 7 MALT lymphomas, 8 Burkitt's lymphoma cell lines, 3 cell lines of multiple myeloma, 15 cases and 4 cell lines of diffuse large B\u2010cell lymphoma and 7 Hodgkin's lymphoma lines. No mutations were found in any of the cases. We conclude that mutations in the <jats:italic>BAD<\/jats:italic> gene do not play a role in the pathogenesis of the major subtypes of human B\u2010cell lymphomas. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22010","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T23:02:48Z","timestamp":1146178968000},"page":"1738-1740","source":"Crossref","is-referenced-by-count":5,"title":["The major subtypes of human B\u2010cell lymphomas lack mutations in BCL\u20102 family member <i>BAD<\/i>"],"prefix":"10.1002","volume":"119","author":[{"given":"Roland","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman K.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne 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