{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:42:33Z","timestamp":1789011753385,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T00:00:00Z","timestamp":1146096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dickkopf\u20101 (DKK\u20101) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis of myeloma bone disease through the suppression of osteoblast differentiation. In this study, serum concentrations of DKK\u20101 were measured in 50 myeloma patients (32 at diagnosis and 18 before and after autologous stem cell transplantation (ASCT), 18 patients with monoclonal gammopathy of undetermined significance (MGUS), and 22 healthy controls. Serum DKK\u20101 levels were increased in MM at diagnosis compared with MGUS (mean \u00b1 SD: 67 \u00b1 54 ng\/mL <jats:italic>vs.<\/jats:italic> 38 \u00b1 13 ng\/mL; <jats:italic>p<\/jats:italic> = 0.006) and controls (31 \u00b1 11 ng\/mL; <jats:italic>p<\/jats:italic> = 0.02), while there was no difference between MGUS patients and controls. Although patients with stage 2 and 3 myeloma had higher DKK\u20101 values than stage 1 patients (79 \u00b1 63 <jats:italic>vs.<\/jats:italic> 40 \u00b1 13; <jats:italic>p<\/jats:italic> = 0.005), no significant correlation between serum DKK\u20101 and myeloma bone disease was observed. Myeloma patients before ASCT also had increased levels of DKK\u20101 (63 \u00b1 77 ng\/mL; <jats:italic>p<\/jats:italic> = 0.03) compared with controls, supporting the notion that DKK\u20101 may be responsible for the suppressed osteoblast activity even in patients with low tumor burden. After ASCT, there was a sustained decrease in DKK\u20101 levels over time, while bone formation markers elevated, suggesting that the reduction of DKK\u20101 levels after ASCT may correlate with the normalization of osteoblast function. These results could provide the basis for developing agents that block DKK\u20101, thus restoring osteoblast function and counteracting the increased osteoclastogenesis observed in myeloma. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22033","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T22:53:18Z","timestamp":1146178398000},"page":"1728-1731","source":"Crossref","is-referenced-by-count":140,"title":["Serum concentrations of Dickkopf\u20101 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation"],"prefix":"10.1002","volume":"119","author":[{"given":"Marianna C.","family":"Politou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Heath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Rahemtulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Szydlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Anagnostopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios A.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter I.","family":"Croucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19465"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00041-7"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.5.966"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201089"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030847"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4940"},{"key":"e_1_2_4_8_2","article-title":"A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and IL\u20106: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma","author":"Gunn WG","journal-title":"Stem Cells"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04374.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00930.x"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05092.x"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.9.3743"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.11.4762.bloodjournal87114762"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0301212"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403423"},{"key":"e_1_2_4_17_2","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1182\/blood.V96.8.2697","article-title":"Biochemical markers of bone turnover following high\u2010dose chemotherapy and autografting in multiple myeloma","volume":"96","author":"Clark RE","year":"2000","journal-title":"Blood"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109097705"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:11:36Z","timestamp":1696903896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,18]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1002\/ijc.22033"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22033","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,18]]}}}