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We evaluated the association between body weight and ER\/PR defined breast cancer risk stratified by postmenopausal hormone (PMH) use and a family history of breast cancer in the population\u2010based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Relative body weight was measured by body mass index (kg\/m<jats:sup>2<\/jats:sup>) based on self\u2010reported weight and height collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratios derived from Cox proportional hazards regression models. During an average of 8.3\u2010year follow\u2010up, 1,188 invasive breast cancer cases with known ER and PR status were diagnosed. When comparing to normal weight group, we observed a positive association between obesity and risk for the development of ER+ PR+ tumors (RR = 1.67, 95% CI = 1.34\u20132.07) and an inverse association for the development of all PR\u2212 tumors (RR = 0.68, 95% CI = 0.47\u20130.98). Statistically significant heterogeneity was observed in the RRs between ER+ PR+ tumors and all PR\u2212 tumors (<jats:italic>p<\/jats:italic><jats:sub>heterogeneity<\/jats:sub> &lt; 0.0001). The positive association of obesity with the development of ER+ PR+ tumors was confined to never\u2010users of PMHs (RR = 1.90 (CI 95%:1.38\u20132.61)) and to those without a family history of breast cancer (RR = 1.82 (CI 95%:1.45\u20132.29)). Our results support the hypothesis that excess endogenous estrogen due to obesity contributes to an increased risk of ER+ PR+ postmenopausal breast cancer. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22034","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T22:52:27Z","timestamp":1146178347000},"page":"1683-1689","source":"Crossref","is-referenced-by-count":89,"title":["Body weight and postmenopausal breast cancer risk defined by estrogen and progesterone receptor status among Swedish women: A prospective cohort study"],"prefix":"10.1002","volume":"119","author":[{"given":"Reiko","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Rylander\u2010Rudqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehira","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036096"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.6.514"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1053>3.0.CO;2-T"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90286-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(78)90287-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-1-174"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(86)90118-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0021-9258(17)38062-6","article-title":"Estrogen control of progesterone receptor in human breast cancer. 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