{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:49:18Z","timestamp":1790966958109,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T00:00:00Z","timestamp":1152057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"New Scholar in Aging Award, Ellison Medical Foundation"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG01751"],"award-info":[{"award-number":["AG01751"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["CA102029"],"award-info":[{"award-number":["CA102029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["ES11045"],"award-info":[{"award-number":["ES11045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The major etiological agent in skin cancer is exposure to UV\u2010irradiation and the concomitant DNA damage. UV\u2010induced DNA lesions, such as thymine dimers, block DNA synthesis by the major DNA polymerases and inhibit the progression of DNA replication. Bypass of thymine dimers and related lesions is dependent on the translesion polymerase DNA polymerase \u03b7 (Pol\u03b7). In the inherited disorder, xeroderma pigmentosum variant (XPV), inactivation of Pol\u03b7 results in extreme sensitivity to UV light and a marked increase in the incidence of skin cancer. Here, we tested the hypothesis that somatic mutations and\/or polymorphisms in the <jats:italic>POLH<\/jats:italic> gene that encodes Pol\u03b7 are associated with the induction of UV\u2010dependent skin cancers. We sequenced the exonic regions of the Pol\u03b7 open reading frame in DNA from 17 paired samples of squamous cell skin carcinoma and adjacent histologically normal tissue. We analyzed approximately 120,000 nucleotides and detected no mutations in <jats:italic>POLH<\/jats:italic> in the tumors. However, we identified 6 different single\u2010nucleotide polymorphisms, 3 of them previously undocumented, which were present in both the tumor and paired normal tissue. We conclude that neither mutations nor polymorphisms in the coding regions of <jats:italic>POLH<\/jats:italic> are required for the generation of human skin squamous cell carcinoma. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22099","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T08:18:57Z","timestamp":1152173937000},"page":"2225-2227","source":"Crossref","is-referenced-by-count":8,"title":["Mutations in DNA polymerase \u03b7 are not detected in squamous cell carcinoma of the skin"],"prefix":"10.1002","volume":"119","author":[{"given":"Eitan","family":"Glick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy B.","family":"Kiviat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Loeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272307"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1999.0143"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.212"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.12.3491"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/21447"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.23.15975"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2003.00124.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02352"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203842"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.24.7303"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1451"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.11.029"},{"key":"e_1_2_6_14_2","first-page":"5366","article-title":"DNA polymerase kappa, implicated in spontaneous and DNA damage\u2010induced mutagenesis, is overexpressed in lung cancer","volume":"61","author":"O\u2010Wang J","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_15_2","first-page":"161","article-title":"Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: negative regulation of POLK promoter activity by p53","volume":"25","author":"Wang Y","year":"2004","journal-title":"Int J Oncol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1158\/0008-5472.325.65.1","article-title":"Up\u2010regulation of the error\u2010prone DNA polymerase kappa promotes pleiotropic genetic alterations and tumorigenesis","volume":"65","author":"Bavoux C","year":"2005","journal-title":"Cancer Res"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22099","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:38:37Z","timestamp":1697488717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,5]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1002\/ijc.22099"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22099","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,5]]}}}