{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:09:00Z","timestamp":1784740140881,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2006,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clonotypic T\u2010cell receptor (TCR) is a potential target antigen for specific immunotherapy of cutaneous T\u2010cell lymphoma (CTCL). We identified T\u2010cell epitopes from the rearranged TCR \u03b2 chain of the malignant T\u2010cell population by the \u201creverse immunology\u201d approach. Peptide\u2010specific T\u2010cell lines were generated against predicted epitopes and tested for the recognition of tumor cells and cells transfected with the full\u2010length DNA coding for TCRV \u03b2 chain. Two peptides derived from the clonotypic TCRV\u03b2 of a HLA\u2010A2 positive patient could induce peptide\u2010specific T cells from peripheral blood mononuclear cells of healthy donors and the patient as assessed by IFN\u2010\u03b3 ELISpot assay. Furthermore, the reactive CTLs efficiently recognized autologous S\u00e9zary tumor cells, as well as HLA\u2010A2 positive 293 cells transfected with recombinant plasmid expressing the corresponding TCRV\u03b229 protein. Similar results were obtained in a HLA\u2010A3+ patient for TCRV\u03b27\u2010J\u03b22.7. In conclusion, our experiments show that the TCR \u03b2 chain harbors epitopes suitable as targets for specific vaccination which might be a promising approach for the specific immunotherapy of cutaneous T\u2010cell lymphoma patients. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22113","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T17:48:11Z","timestamp":1153417691000},"page":"2476-2480","source":"Crossref","is-referenced-by-count":5,"title":["Identification of HLA class I dependent immunogenic peptides from clonotypic TCR\u03b2 expressed in cutaneous T\u2010cell lymphoma"],"prefix":"10.1002","volume":"119","author":[{"given":"Jinyang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"M\u00fcller\u2010Berghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Duc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Kl\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiltrud","family":"Sch\u00f6nhaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schwinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergij","family":"Goerdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eichm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Dippel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,26]]},"reference":[{"key":"e_1_2_4_2_2","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze R","year":"1997","journal-title":"Blood"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03705.x"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000218803"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072099"},{"key":"e_1_2_4_6_2","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1073\/pnas.98.2.629","article-title":"Serological detection of cutaneous T\u2010cell lymphoma\u2010associated antigens","volume":"98","author":"Eichm\u00fcller S","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05651.x"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199906)188:2<146::AID-PATH334>3.0.CO;2-7"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03714.x"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03715.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.5.2714"},{"key":"e_1_2_4_12_2","first-page":"659","article-title":"Molecular immunoglobulin\/T\u2010cell receptor clonality analysis in cutaneous lymphoproliferations. 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