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Centrosome aberrations have recently been implicated in the induction of aneuploidy in many human malignancies including MCL by malsegregation of chromosomes during anaphase of mitosis. Recently, we showed that centrosome aberrations occur more frequently in tetraploid MCL as compared to their diploid counterparts. To test the hypothesis of an association between tetraploidization and expression of genes coding for centrosomal proteins in MCL, tumor RNA of 33 MCL samples was hybridized to custom\u2010made cDNA microarrays, representing 4,628 distinct human gene\u2010specific fragments, with particular enrichment for cancer\u2010relevant (<jats:italic>n<\/jats:italic> = 2,440) and centrosome\u2010associated genes (<jats:italic>n<\/jats:italic> = 359). Notably, 4 of the 6 most significant genes (<jats:italic>CAMKK2<\/jats:italic>, <jats:italic>PCNT2<\/jats:italic>, <jats:italic>TUBGCP3<\/jats:italic>, <jats:italic>TUBGCP4<\/jats:italic>) discriminating between diploid and near\u2010tetraploid MCL code for centrosomal proteins. As confirmed by quantitative RT\u2010PCR analysis, calcium\/calmodulin\u2010dependent protein kinase II (<jats:italic>CAMKK2)<\/jats:italic>, pericentrin (<jats:italic>PCNT2<\/jats:italic>) and \u03b3\u2010tubulin complex associated protein 3 (<jats:italic>TUBGCP3<\/jats:italic>) were all found to be significantly higher expressed in near\u2010tetraploid than in diploid MCL samples. In conclusion, we describe a comprehensive expression signature of a set of genes associated with tetraploidization in MCL. The high expression level of centrosome\u2010associated gene products in blastoid MCL matches the description of more frequent centrosome aberrations in this MCL variant. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22404","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T18:18:01Z","timestamp":1169144281000},"page":"1669-1677","source":"Crossref","is-referenced-by-count":16,"title":["Expression of centrosome\u2010associated gene products is linked to tetraploidization in mantle cell 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