{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:38Z","timestamp":1764688598339},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individual variations in the ability to cope with DNA damage by DNA repair may be essential for the response to chemotherapy, since cancer cells from patients with an effective DNA repair may survive treatment. We have studied the effect on time to treatment failure (TTF) and overall survival (OS) of polymorphism in the DNA repair genes <jats:italic>ERCC1, ERCC2<\/jats:italic> and <jats:italic>XRCC3<\/jats:italic>, and in the apoptotic genes <jats:italic>PPP1R13L<\/jats:italic> and <jats:italic>CD3EAP<\/jats:italic> in 348 patients with multiple myeloma undergoing autologous bone marrow transplantation. Carriers of the variant C\u2010allele of <jats:italic>ERCC2<\/jats:italic> K751Q, the variant T\u2010allele of <jats:italic>XRCC3<\/jats:italic> T241M and the variant A\u2010allele of <jats:italic>CD3EAP<\/jats:italic> G\u201021A had a 1.3\u2010fold, 1.8\u2010fold and 1.9\u2010fold longer TTF, respectively, than homozygous wild type carriers (<jats:italic>p<\/jats:italic> = 0.006, <jats:italic>p<\/jats:italic> = 0.004, <jats:italic>p<\/jats:italic> &lt; 0.001). The polymorphism <jats:italic>CD3EAP<\/jats:italic> G\u201021A also had significant effect on OS (<jats:italic>p<\/jats:italic> &lt; 0.045). The polymorphism <jats:italic>ERCC2<\/jats:italic> K751Q may to be related to sex, since the prolonged TTF was only seen in women (<jats:italic>p<\/jats:italic> = 0.001). Carriers of the combination of variant alleles of <jats:italic>ERCC2<\/jats:italic> K751Q and <jats:italic>XRCC3<\/jats:italic> T241M had 2.8\u2010fold longer TTF (<jats:italic>p<\/jats:italic> = 0.0002). This indicates that suboptimal repair of both DNA mechanisms favors prolonged TTF and that polymorphism in <jats:italic>ERCC2, XRCC3<\/jats:italic> and <jats:italic>CD3EAP<\/jats:italic> predicts the outcome for patients treated with autologous stem cell transplantation. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22411","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T23:28:44Z","timestamp":1164670124000},"page":"1036-1045","source":"Crossref","is-referenced-by-count":42,"title":["Polymorphisms in the genes <i>ERCC2, XRCC3<\/i> and <i>CD3EAP<\/i> influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation"],"prefix":"10.1002","volume":"120","author":[{"given":"Annette","family":"Vangsted","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gimsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias W.","family":"Klausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn 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