{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T13:14:33Z","timestamp":1770729273102,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (<jats:italic>n<\/jats:italic>= 7,476), non\u2010Hodgkin lymphoma (NHL) (<jats:italic>n<\/jats:italic>= 25,941), or chronic lymphocytic leukemia (CLL) (<jats:italic>n<\/jats:italic>= 7,764), using a large population\u2010based database. Family history of cancer was based on a diagnosis of any cancer in 110,862 first\u2010degree relatives. We found increased relative risk (RR) (1.81, 95% confidence interval (CI): 1.04\u20133.16) of breast cancer among HL patient with positive (<jats:italic>vs.<\/jats:italic>negative) family history of cancer. Among CLL patients with positive (<jats:italic>vs.<\/jats:italic>negative) family history of cancer, we observed elevated risks of bladder (RR = 3.53, 95% CI: 1.31\u20139.55) and prostate cancer (RR = 2.15, 95% CI: 1.17\u20133.94). For NHL patients with positive (<jats:italic>vs.<\/jats:italic>negative) family history of cancer, we observed non\u2010significantly increased risk of non\u2010melanoma skin cancer (RR = 1.94, 95% CI: 0.86\u20134.38) and lung cancer (RR = 1.99, 95% CI: 0.73\u20135.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk\u2010factors for selected second tumors following lymphoproliferative disorders. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22414","type":"journal-article","created":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T23:06:00Z","timestamp":1164668760000},"page":"1099-1102","source":"Crossref","is-referenced-by-count":33,"title":["Risk of second malignant neoplasms among lymphoma patients with a family history of cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Ola","family":"Landgren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laveta","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gridley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Mellemkjaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn R.","family":"Goldin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois B.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"SEER Cancer statistics review, 1975\u20132003","author":"Ries LAG","year":"2006"},{"key":"e_1_2_6_3_2","first-page":"2575","volume-title":"Cancer: principles and practice of oncology","author":"van Leeuwen FE","year":"2005"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/8.suppl_1.S115"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.131"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji290"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.4.465"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.13.971"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1535"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1259"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1998)15:3<225::AID-GEPI2>3.0.CO;2-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860152619214"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20189"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21745"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4620"},{"key":"e_1_2_6_16_2","first-page":"539","volume-title":"Non\u2010Hodgkin's lymphomas","author":"Travis LB","year":"2004"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1979"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.038"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables (with discussion)","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc B"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.3698"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.3.182"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.2200"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.20.1530"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0161:LCATFH]2.0.CO;2"},{"key":"e_1_2_6_25_2","first-page":"637","volume-title":"Cancer epidemiology and prevention","author":"Blot WJ","year":"1996"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.431.13.3"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601388"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0379"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.18.1422"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.7.524"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.08.128"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2454"},{"key":"e_1_2_6_33_2","series-title":"Monographs on the evaluation of carcinogenic risks to humans\u2013overall evaluation of carcinogenety","author":"World Health Organisation","year":"1987"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602263"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0341"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj001"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T04:54:27Z","timestamp":1736657667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1002\/ijc.22414"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22414","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]}}}