{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:36:08Z","timestamp":1791005768089,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T00:00:00Z","timestamp":1167868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of human papillomavirus (HPV) infection is high in the oropharyngeal mucosal regions, of which the tonsil is the most commonly affected. There may be a link between HPV and the pathogenesis of tonsillar cancer (TC), because of common anatomical characteristics between cervical and tonsillar cancer. We aimed to clarify whether HPV directly affects the oncogenesis and biologic behavior of TC by making a comparison between infection prevalence, physical status and viral loading numbers, and clinicopathologic prognostic factors. To compare HPV\u2010related molecules between TC and tonsillitis (CFT), p16, survivin, HIF\u20101\u03b1, skp\u20101, cyclin A, cyclin B1, c\u2010myc and EGFR were investigated. We observed a significant difference in HPV prevalence between 52 TCs and 69 CFTs (73.1% <jats:italic>vs.<\/jats:italic> 11.6%), and most of the HPVs were type 16 (87.2%) and nonepisomal (94.1%). Most TCs associated with HPV arose from the tonsillar crypts, and tended to be inverted and poorly differentiated. Compared with HPV\u2010negative TC, HPV\u2010positive TC showed a strong association with p16 overexpression (<jats:italic>p<\/jats:italic> &lt; 0.0001), and an inverse association with EGFR amplification (<jats:italic>p<\/jats:italic> = 0.0478). HPV\u201016 integration status was strongly associated with c\u2010myc amplification (<jats:italic>p<\/jats:italic> = 0.034) and HIF\u20101\u03b1 overexpression (<jats:italic>p<\/jats:italic> = 0.022). HPV\u201016 integration could be directly related to tonsillar carcinogenesis initially in tonsillar crypts, followed by cell cycle aberration such as p16 overexpression related to the G1\u2010S phase. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22464","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T22:25:41Z","timestamp":1167949541000},"page":"1418-1425","source":"Crossref","is-referenced-by-count":187,"title":["HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c\u2010myc during tumor formation"],"prefix":"10.1002","volume":"120","author":[{"given":"Se\u2010Heon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bon\u2010Seok","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suki","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongmee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeryoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ryul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moo Joo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Man","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Chang","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam 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