{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:36Z","timestamp":1791295716019,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T00:00:00Z","timestamp":1167868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regular aspirin and non\u2010aspirin nonsteroidal anti\u2010inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect of NSAIDs on the risk of other cancers remains unclear. To evaluate whether use of aspirin or other specific NSAIDs protects against lung cancer, we conducted a case\u2013control study nested in a cohort of subjects 40\u201384 years old in 1995\u20132004, without a diagnosis of cancer before the study start date, and with at least 2 years of enrollment with a general practitioner providing data to the The Health Improvement Network (THIN) database in the UK. Patients who had a first diagnosis of primary lung cancer during the study period were considered cases. A random sample of 10,000 controls was frequency\u2010matched to the cases for age, sex and calendar year. The index date for exposure definition was 1 year before the date of diagnosis for cases and 1 year before a random date within the study period for controls. Relative risks and 95% confidence intervals were estimated using conditional logistic regression stratified for matching factors. Factors such as smoking, chronic obstructive pulmonary disease, cardiovascular diseases and body mass index were introduced in the model. We identified 4,336 cases with primary incident lung cancer (incidence rate 7.6 per 10,000 person\u2010years). Compared with subjects with no prescription of non\u2010aspirin NSAID prior to the index date, the risk of lung cancer was 0.76 (0.61\u20130.94) among those who received a prescription the previous year and had a treatment duration of at least 1 year. The corresponding relative risk was 1.15 (0.99\u20131.34) for aspirin. In conclusion, prescription of non\u2010aspirin NSAIDs for at least 1 year might be associated with a slightly reduced risk of lung cancer. Aspirin was not associated with a risk reduction, perhaps due to residual confounding. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22514","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T22:27:47Z","timestamp":1167949667000},"page":"1565-1572","source":"Crossref","is-referenced-by-count":45,"title":["Nonsteroidal anti\u2010inflammatory drugs and risk of lung cancer"],"prefix":"10.1002","volume":"120","author":[{"given":"Sonia","family":"Hern\u00e1ndez\u2010D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Garc\u00eda Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.4.252"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-3-28"},{"key":"e_1_2_5_4_2","first-page":"559","article-title":"Aspirin, ibuprofen, and other non\u2010steroidal anti\u2010inflammatory drugs in cancer prevention: a critical review of non\u2010selective COX\u20102 blockade (review)","volume":"13","author":"Harris R","year":"2005","journal-title":"Oncol Rep"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.1.10"},{"key":"e_1_2_5_6_2","first-page":"4997","article-title":"Expression of cyclooxygenase\u20102 in human lung carcinoma","volume":"58","author":"Wolff H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.4.543"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(00)00132-X"},{"key":"e_1_2_5_9_2","first-page":"775","article-title":"Non\u2010small cell lung cancer cycloxygenase activity and proliferation are inhibited by non\u2010steroidal antiinflammatory drugs","volume":"18","author":"Hida T","year":"1998","journal-title":"Anticancer Res"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(92)90275-Z"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01902140150216783"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.313"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.1.47"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.3.748"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.14236\/jhi.v12i3.124"},{"key":"e_1_2_5_16_2","unstructured":"NHS Terminology Service. 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