{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:42:59Z","timestamp":1790818979374,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T00:00:00Z","timestamp":1168992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to document the prevalence of diabetes among newly diagnosed cancer patients and to evaluate the influence of diabetes on stage at diagnosis, treatment and overall survival. We performed a population\u2010based analyses of all 58,498 cancer patients newly diagnosed between 1995 and 2002 in the registration area of the Eindhoven Cancer Registry. Stage of cancer, cancer treatment and comorbidities were actively collected by hospital medical records review. Follow\u2010up of all patients was completed until January 1, 2005. Nine percent of all cancer patients had diabetes at the time of cancer diagnosis. The prevalence of diabetes was highest among patients with cancer of the pancreas (19%), uterus (14%) and among young men with kidney cancer (8%). Colon, breast and ovarian cancer patients with diabetes were more often diagnosed with a higher tumour stage (<jats:italic>p<\/jats:italic> &lt; 0.05). Patients with diabetes and cancer of the oesophagus, colon, breast and ovary were treated less aggressively compared to those without diabetes (<jats:italic>p<\/jats:italic> &lt; 0.05). During the follow\u2010up period 3,902 of 5,555 cancer patients with diabetes died and 29,909 of 52,943 cancer patients without diabetes died. For all cancers combined, in a multivariate cox\u2010regression model, adjusting for age, gender, stage, treatment and cardiovascular disease, patients with diabetes experienced a significant increase in overall mortality (HR = 1.44, 95% CI 1.40\u20131.49), ranging however from 0 to 40% for different types of cancer, compared to those without diabetes. In conclusion, diabetic cancer patients frequently were treated less aggressively and had a worse prognosis compared to those without diabetes. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22532","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T21:50:55Z","timestamp":1169070655000},"page":"1986-1992","source":"Crossref","is-referenced-by-count":276,"title":["Less aggressive treatment and worse overall survival in cancer patients with diabetes: A large population based analysis"],"prefix":"10.1002","volume":"120","author":[{"given":"Lonneke V.","family":"van de Poll\u2010Franse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Houterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryska L.G.","family":"Janssen\u2010Heijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus W.","family":"Dercksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem W.","family":"Coebergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm R.","family":"Haak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/11.4.365"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.04.008"},{"key":"e_1_2_6_4_2","first-page":"1681","article-title":"[Disease burden of diabetes mellitus type II in the Netherlands: incidence, prevalence and mortality]","volume":"145","author":"Baan CA","year":"2001","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.13.1450"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14116-5"},{"key":"e_1_2_6_8_2","first-page":"1419","article-title":"[Estimation of the number of new patients with type 2 diabetes in the Netherlands: over 65.000 per year aged 50 years and older]","volume":"147","author":"Dekker JM","year":"2003","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(02)00130-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520440059037"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/10.suppl_4.S79"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407143310203"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/152091501300209633"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.18.1360"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970502)71:3<360::AID-IJC9>3.0.CO;2-W"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10685"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1415-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008822917449"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120001141"},{"key":"e_1_2_6_20_2","volume-title":"Cancer incidence, care and survival in the South of the Netherlands, 1955\u20131999: a report of the Eindhoven Cancer Registry with cross border implications","author":"Coebergh JWW","year":"2001"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00154-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_23_2","unstructured":"Nationaal Kompas Volksgezondheid version 3.2. Website RIVM (www.rivm.nl\/vtv) accessed June 15 2005."},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051122"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji375"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.7.620"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10384-1"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690607"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115732"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.16.1118"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.7.885"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2123::AID-CNCR6>3.0.CO;2-W"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.07.125"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh161"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.42"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg100"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0062"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10593"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(96)00326-0"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:39:57Z","timestamp":1697240397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,17]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/ijc.22532"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22532","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,17]]}}}