{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:33:41Z","timestamp":1791146021381,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) patients are highly immunocompromised, but the underlying mechanism responsible for this state remains obscure. Recent studies demonstrated that <jats:italic>FOXP3<\/jats:italic>, which is a master control gene of naturally occurring regulatory T (Treg) cells, is expressed in the tumor cells from a subset of patients with ATLL. Since most ATLL cells express both CD4 and CD25, these tumors might originate from CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>FOXP3<jats:sup>+<\/jats:sup> Treg cells, based on their phenotypic characteristics. However, whether ATLL cells actually function as Treg cells has not yet been clearly demonstrated. Here, we show that ATLL cells from a subset of patients are not only hypo\u2010responsive to T\u2010cell receptor\u2010mediated activation, but also suppress the proliferation of autologous CD4<jats:sup>+<\/jats:sup> non\u2010ATLL cells. Furthermore, ATLL cells from this subset of patients secrete only small amounts of IFN\u2010\u03b3, and suppress IFN\u2010\u03b3 production by autologous CD4<jats:sup>+<\/jats:sup> non\u2010ATLL cells. These are the first data showing that ATLL cells from a subset of patients function as Treg cells in an autologous setting. The present study provides novel insights into understanding the immunopathogenesis of ATLL, <jats:italic>i.e.<\/jats:italic>, how HTLV\u20101\u2010infected cells can survive in the face of host immune responses. It also adds to our understanding of ATLL patients' severely immunocompromised state. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22536","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T08:37:06Z","timestamp":1170491826000},"page":"2052-2057","source":"Crossref","is-referenced-by-count":77,"title":["Regulatory T\u2010cell function of adult T\u2010cell leukemia\/lymphoma 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