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A total of 773 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 163 of non\u2010Hodgkin's lymphoma (NHL) and 1,681 population\u2010based controls were included. The controls were randomly selected from the French population and were frequency matched with the cases on age and gender. Cancer history in first\u2010 and second\u2010degree relatives was reported by the mothers in a structured telephone questionnaire that was the same for the cases and controls. Odds ratios (ORs) were estimated using an unconditional regression model taking into account the stratification variables and potential confounders. A family history of cancer was associated with an increased risk of HL (OR = 1.5 [1.0\u20132.2]) and NHL (OR = 1.8 [1.3\u20132.5]), but not AL (OR = 1.0 [0.9\u20131.2]). The ORs were higher when at least 2 relatives had a history of cancer or when 1 case occurred before age 46 years. Only HL was significantly associated with a family history of hematopoietic malignancies (OR = 2.0 [1.0\u20133.8]), mainly because of a significant association with a history of HL (OR = 5.4 [1.3\u201322]). In conclusion, the study findings support the hypothesis of familial susceptibility to childhood lymphoma, but do not suggest familial susceptibility to childhood AL. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22624","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T19:44:41Z","timestamp":1172691881000},"page":"119-126","source":"Crossref","is-referenced-by-count":41,"title":["Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non\u2010Hodgkin's lymphoma: The ESCALE study 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