{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:38:39Z","timestamp":1790368719072,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T00:00:00Z","timestamp":1174262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Moderate to high\u2010dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low\u2010dose chest X\u2010rays, particularly in individuals at increased genetic risk. We analyzed case\u2010control data from the Breast Cancer Family Registry. Self\u2010reported data on therapeutic and diagnostic radiation exposures to the chest were available for 2,254 breast cancer cases and 3,431 controls (1,556 unaffected sisters and 1,875 unrelated population controls). We used unconditional logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (CI) associated with radiation exposure, after adjusting for age, study center, country of birth, and education. Increased risks for breast cancer were found for women who had radiotherapy for a previous cancer (OR = 3.55, CI = 1.47\u20138.54) and diagnostic chest X\u2010rays for tuberculosis (OR = 2.49, CI = 1.82\u20133.40) or pneumonia (OR = 2.19, CI = 1.38\u20133.47). Risks were highest for women with a large number of exposures at a young age or exposed in earlier calendar years. There was no evidence of increased risk associated with other diagnostic chest X\u2010rays (not including tuberculosis or pneumonia), both in women with and without indicators of increased genetic risk (<jats:italic>i.e.<\/jats:italic>, diagnosed at age &lt;40 years or family history of breast cancer). Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic>. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22668","type":"journal-article","created":{"date-parts":[[2007,3,19]],"date-time":"2007-03-19T20:33:43Z","timestamp":1174336423000},"page":"386-394","source":"Crossref","is-referenced-by-count":60,"title":["Medical radiation exposure and breast cancer risk: Findings from the Breast Cancer Family Registry"],"prefix":"10.1002","volume":"121","author":[{"given":"Esther M.","family":"John","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda I.","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Milne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian S.","family":"Dite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L.","family":"Andrulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Southey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee W.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Whittemore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"UNSCEAR.Sources and effects of ionizing radiation: United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000. Report to the general assembly with scientific annexes United Nations 2000."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1965.1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196809262791301"},{"key":"e_1_2_6_5_2","first-page":"1032","article-title":"Breast cancer following multiple fluoroscopies during artificial pneumothorax treatment of pulmonary tuberculosis","volume":"100","author":"Myrden JA","year":"1969","journal-title":"Can Med Assoc J"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.1.25"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603213341201"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970315)79:6<1203::AID-CNCR20>3.0.CO;2-2"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830201)51:3<521::AID-CNCR2820510325>3.0.CO;2-U"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-8-200410190-00006"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460030097037"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203193261201"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.20.1679"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/77.3.689"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911093211902"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.2307\/3579360"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2307\/3577890"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/81.17.1307"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200008150-00009"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911093211901"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1868"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92140-5"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3082"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2002)158[0220:REOBCR]2.0.CO;2"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020201106117"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-200307000-00011"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr801"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0376"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21298"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.2307\/2532441"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.4.465"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.13.971"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.487"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf289"},{"key":"e_1_2_6_35_2","first-page":"229","article-title":"Breast cancer after multiple chest fluoroscopies: second follow\u2010up of Massachusetts women with tuberculosis","volume":"49","author":"Hrubec Z","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1148\/38.3.274"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1148\/38.3.281"},{"key":"e_1_2_6_38_2","volume-title":"Preventing breast cancer: the story of a major, proven, preventable cause of this disease","author":"Gofman JW","year":"1996"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70014-1"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008911902994"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200206000-00006"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.005"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.2307\/3580039"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90164-8"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1989.01670190055005"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.199.4.280"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198401000-00007"},{"key":"e_1_2_6_48_2","first-page":"691","article-title":"Thyroid carcinoma and hyperparathyroidism after radiation therapy for adolescent acne vulgaris","volume":"110","author":"De Jong SA","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14169.x"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.24.1848"},{"key":"e_1_2_6_51_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1007"},{"key":"e_1_2_6_52_2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/jama.1977.03270350049020","article-title":"Breast cancer induced by radiation. Relation to mammography and treatment of acne","volume":"237","author":"Simon N","year":"1977","journal-title":"JAMA"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.03670120017005"},{"key":"e_1_2_6_54_2","first-page":"479","volume-title":"X rays and radium in the treatment of diseases of the skined","author":"Cipollaro AC","year":"1967"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013796112348"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.3126"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22668","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:38:09Z","timestamp":1696905489000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,18]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,7,15]]}},"alternative-id":["10.1002\/ijc.22668"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22668","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,18]]}}}