{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:50:20Z","timestamp":1776840620364,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,16]],"date-time":"2007-04-16T00:00:00Z","timestamp":1176681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus\u2010I (HTLV\u2010I) causes adult T\u2010cell leukemia\/lymphoma (ATL) and HTLV\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class\u2010I (A,B) and class\u2010II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM\/TSP patients and 190 population\u2010based, asymptomatic HTLV\u2010I\u2010infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence &gt;50% of asymptomatic carriers) and by prevalence quartile. HTLV\u2010I proviral load between asymptomatic carriers with common <jats:italic>versus<\/jats:italic> uncommon types was compared by <jats:italic>t<\/jats:italic>\u2010test. ATL differed from asymptomatic carriers in overall DQB1 allele and class\u2010I haplotype frequencies (<jats:italic>p<\/jats:italic> \u2264\u2264 0.04). ATL risk was increased significantly with common HLA\u2010B (OR 2.25, 95% CI 1.19\u20134.25) and DRB1 (OR 2.11, 95% CI 1.13\u20133.40) alleles. Higher prevalence HLA\u2010B alleles were associated with higher ATL risk (OR 1.14 per quartile, <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.02). Asymptomatic carriers with common HLA\u2010B alleles had marginally higher HTLV\u2010I proviral load (<jats:italic>p<\/jats:italic> = 0.057). HAM\/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM\/TSP risk, was increased with higher prevalence HLA\u2010B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia\/lymphoma. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22767","type":"journal-article","created":{"date-parts":[[2007,4,16]],"date-time":"2007-04-16T18:18:22Z","timestamp":1176747502000},"page":"1092-1097","source":"Crossref","is-referenced-by-count":18,"title":["Risk of human T\u2010lymphotropic virus type I\u2010associated diseases in Jamaica with common HLA types"],"prefix":"10.1002","volume":"121","author":[{"given":"James 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