{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:09:21Z","timestamp":1791022161925,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T00:00:00Z","timestamp":1178582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly 40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal center B cell\u2010like (GCB) and activated B cell\u2010like (ABC) subtypes by gene expression and immunohistochemical profiling. Using microarray analysis on prototypic cell lines, we identified microRNAs (\n                    <jats:italic>miR\u2010155<\/jats:italic>\n                    ,\n                    <jats:italic>miR\u201021<\/jats:italic>\n                    and\n                    <jats:italic>miR\u2010221<\/jats:italic>\n                    ) that were more highly expressed in ABC\u2010type than GCB\u2010type cell lines. These microRNAs were over\u2010expressed in\n                    <jats:italic>de novo<\/jats:italic>\n                    DLBCL (\n                    <jats:italic>n<\/jats:italic>\n                    = 35), transformed DLBCL (\n                    <jats:italic>n<\/jats:italic>\n                    = 14) and follicular center lymphoma cases (\n                    <jats:italic>n<\/jats:italic>\n                    = 27) compared to normal B cells. Consistent with the cell line model, expression levels were higher in DLBCL cases with an ABC\u2010type immunophenotype than those that were GCB\u2010type (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Moreover, using multivariate analysis we found that expression of\n                    <jats:italic>miR\u201021<\/jats:italic>\n                    was an independent prognostic indicator in\n                    <jats:italic>de novo<\/jats:italic>\n                    DLBCL (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Interestingly, expression levels of both\n                    <jats:italic>miR\u2010155<\/jats:italic>\n                    and\n                    <jats:italic>miR\u201021<\/jats:italic>\n                    were also higher in nonmalignant ABC than in GCB cells. As we also demonstrate that expression of microRNAs can be measured reliably from routine paraffin\u2010embedded biopsies of more than 8\u2010years\u2010old (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), we suggest that microRNAs could be clinically useful molecular markers for DLBCL as well as other cancers. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.22800","type":"journal-article","created":{"date-parts":[[2007,5,8]],"date-time":"2007-05-08T10:49:10Z","timestamp":1178621350000},"page":"1156-1161","source":"Crossref","is-referenced-by-count":330,"title":["Microrna expression distinguishes between germinal center B cell\u2010like and activated B cell\u2010like subtypes of diffuse large B cell lymphoma"],"prefix":"10.1002","volume":"121","author":[{"given":"Charles H.","family":"Lawrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamit","family":"Soneji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Marafioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.O.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Palazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Cattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Enver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Mager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Boultwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Wainscoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian 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