{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:21:45Z","timestamp":1790968905334,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies investigating the association between p53 codon 72 polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline and Embase databases. This meta\u2010analysis included 12 case\u2010control studies, which included 1,665 gastric cancer cases and 2,358 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [Arg\/Arg odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.79, 1.16; Pro\/Pro (OR = 1.21, 95% CI = 0.92, 1.58); Pro\/Arg (OR = 0.95, 95% CI = 0.79, 1.14)] between gastric cancer and noncancer patients. When stratifying for race, results were similar except that patients with gastric cancer had a significantly lower frequency of Arg\/Arg (OR = 0.84, 95% CI = 0.72, 0.99) than noncancer patients among Asians. Stratified the various studies by the location, stage, Lauren's classification, and histological differentiation of gastric cancer, we found that (<jats:italic>i<\/jats:italic>) patients with cardia gastric cancer had a significantly higher frequency of Pro\/Pro (OR = 3.20, 95% CI = 1.46,7.01) than those with noncardia gastric cancer among Asians; (<jats:italic>ii<\/jats:italic>) patients with advanced (stage III\/IV) gastric cancer had a significantly higher frequency of Arg\/Arg (OR = 1.48, 95% CI = 1.01, 2.16) than those with early (stage I\/II) gastric cancer among Asians; (<jats:italic>iii<\/jats:italic>) patients with poor differentiation had a significantly lower frequency of Pro\/Pro (OR = 0.13, 95% CI = 0.03, 0.64) than those with well differentiation among Caucasians. This meta\u2010analysis suggests that the p53 codon 72 polymorphism may be associated with gastric cancer among Asians, and that difference in genotype distribution may be associated with the location, stage, and histological differentiation of gastric cancer. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22833","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T15:16:39Z","timestamp":1180710999000},"page":"1481-1486","source":"Crossref","is-referenced-by-count":104,"title":["P53 codon 72 polymorphism and gastric cancer: A meta\u2010analysis of the literature"],"prefix":"10.1002","volume":"121","author":[{"given":"Yong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan\u2010Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2010Xiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao\u2010Ling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.9.747"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01212724"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1905840"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81871-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70356-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geg008"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.09.003"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22057"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0173"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00867-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-083-3"},{"key":"e_1_2_5_15_2","volume-title":"Cochrane handbook for systematic reviews of interventions 4.2.6","author":"Higgins JPT","year":"2006"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0853-3"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh229"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-005-0081-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000017447.02220.f5"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10483"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00041-1"},{"key":"e_1_2_5_22_2","first-page":"2151","article-title":"Age\u2010associated increase of codon 72 Arginine p53 frequency in gastric cardia and non\u2010cardia adenocarcinoma","volume":"9","author":"Zhang ZW","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.11.026"},{"key":"e_1_2_5_24_2","first-page":"1115","article-title":"p53 Codon 72 polymorphism and risk of gastric cancer in a Chinese population","volume":"11","author":"Shen H","year":"2004","journal-title":"Oncol Rep"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410009456"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21137"},{"key":"e_1_2_5_27_2","first-page":"944","article-title":"Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer","volume":"52","author":"Lai KC","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.07.004"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2006.21.1.28"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-006-0139-7"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i40.6536"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.1.5"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28000"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10466"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/44432"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11548"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00369-4"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000154325"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/14.6.1085"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.9.2205"},{"key":"e_1_2_5_42_2","first-page":"711","article-title":"p53 Codon 72 polymorphism in breast cancer","volume":"10","author":"Buyru N","year":"2003","journal-title":"Oncol Rep"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2006.09.007"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0241"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/30400"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcbr.2000.0196"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200207000-00017"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009878"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/157.2.885"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1159\/000154275"},{"key":"e_1_2_5_51_2","first-page":"505","article-title":"Point: population stratification: a problem for case\u2010control studies of candidate\u2010gene associations?","volume":"11","author":"Thomas DC","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.22833","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.22833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T20:10:18Z","timestamp":1696795818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.22833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1002\/ijc.22833"],"URL":"https:\/\/doi.org\/10.1002\/ijc.22833","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}