{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:37:58Z","timestamp":1772253478335,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Apc<\/jats:italic> gene\u2010deficient Min and <jats:italic>Apc<\/jats:italic><jats:sup>1309<\/jats:sup> mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild\u2010type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator\u2010activated receptor (PPAR) \u03b1 and \u03b3 agonists or an LPL selective inducer suppresses both high serum lipid levels and intestinal polyp formation in these model animals. Since the general cyclooxygenase inhibitor, indomethacin, is known to suppress intestinal tumor development, but not to affect serum lipids, its influence in Min mice was here investigated. Treatment with 2.5, 5 and 10 ppm indomethacin in the diet for 14 weeks from 6 weeks of age caused significant dose\u2010dependent reduction in serum triglycerides, along with a reduction in the numbers of intestinal polyps to 25% of the untreated control value. LPL mRNA levels in the liver were slightly increased by indomethacin treatment. We further performed oligonucleotide microarray analysis and quantitative PCR analysis and found 8 lipid metabolism\u2010related genes, regulated by sterol regulatory element binding protein\u20101c, to be modulated by indomethacin\u2010treatment in the Min mouse liver. Furthermore, TNF\u03b1 was downregulated. These results indicate that indomethacin might suppress intestinal tumor formation together with a hyperlipidemic state by regulating LPL and other lipid metabolic factors. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.22872","type":"journal-article","created":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T15:17:30Z","timestamp":1180711050000},"page":"1665-1669","source":"Crossref","is-referenced-by-count":20,"title":["Improvement of hyperlipidemia by indomethacin in Min 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