{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:04:25Z","timestamp":1787166265479,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic atrophic gastritis (CAG), a precursor of intestinal gastric cancer, is mostly ascertained noninvasively by serum pepsinogens in epidemiologic studies. However, serological definitions vary widely. We aimed to investigate the impact of this variation on estimated prevalence of CAG and its association with its main risk factors, age and\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection. Serum pepsinogen I and II and antibodies against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    were measured by ELISA among 9,444 women and men aged 50\u201374 years in a population\u2010based cohort study in Saarland\/Germany. Application of the various definitions resulted in a wide range of prevalence estimates of CAG prevalence (2.1%\u20138.2%, with an outlier of 18.8% for one particular definition) and its associations with age and\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection (age adjusted odds ratios, OR, for CagA positive\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection: 0.98\u20134.48). Definitions of CAG based on both pepsinogen I and the pepsinogen I\/II ratio or on the pepsinogen I\/II ratio only revealed much clearer associations with both age and\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection than definitions of CAG based on pepsinogen I only (ORs for\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection: 1.45\u20134.48 and 0.86\u20131.30, respectively). Epidemiologic findings on CAG lack comparability due to the heterogeneity in serologic definitions of CAG. The association of age and\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.22992","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T13:47:11Z","timestamp":1186667231000},"page":"2782-2786","source":"Crossref","is-referenced-by-count":54,"title":["Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff\u2010value"],"prefix":"10.1002","volume":"121","author":[{"given":"Hermann","family":"Brenner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Rothenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie N.","family":"Weck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,9]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"GLOBOCAN 2002: Cancer incidence, mortality and prevalence worldwide, IARC Cancer Base No. 5. version 2.0","author":"Ferlay J","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0931"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023116"},{"key":"e_1_2_6_5_2","unstructured":"SAS Institute Inc. 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