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To clarify ANXA7 biomarker and tumor suppressor function, we analyzed its expression pattern in comparison to the prostate\u2010specific biomarker NKX3.1. Immunohistochemistry\u2010based ANXA7 and NKX3.1 protein expression was analyzed on human tissue microarrays of 4,061 specimens from a wide spectrum of the histopathologically well\u2010characterized tumors in different stages compared to corresponding normal tissues. Decreased ANXA7 expression was mostly associated with high invasive potential in multiple tumors. Although some metastases retained relatively high ANXA7 rates compared to primary cancer tissues, the lymph node metastases from different sites (including prostate and breast) had decreased ANXA7 expression in comparison to the intact lymphatic tissues. Major ANXA7 downregulation pattern was deviated in tumors of glandular (especially neuroendocrine) origin. ANXA7 and NKX3.1 proteins were synexpressed in the male urogenital system and adrenal gland. Gene expression profiling in prostate and breast cancers (SMD) revealed distinct hormone\u2010related profiles for NKX3.1 and ANXA7, where ANXA7 expression correlated with steroid sulfatase which has a pivotal role in steroidogenesis. Abundant protein presence in adrenal gland and its loss in hormone\u2010refractory prostate cancer indicated that ANXA7 can be relevant to steroidogenesis and androgen sensitivity in particular. With tumor suppressor pattern validated in different tumors, ANXA7 can be an attractive diagnostic and therapeutic target associated with the hormone and\/or neurotransmitter\u2010mediated modulation of tumorigenesis. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23008","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T23:53:42Z","timestamp":1187654022000},"page":"2628-2636","source":"Crossref","is-referenced-by-count":39,"title":["ANXA7 expression represents hormone\u2010relevant tumor suppression in different 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