{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:02:19Z","timestamp":1792155739009,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,23]],"date-time":"2007-08-23T00:00:00Z","timestamp":1187827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic inflammation has been proposed as the possible causal mechanism that explains the observed association between certain risk factors, such as the use of talcum powder (talc) in the pelvic region and epithelial ovarian cancer. To address this issue we evaluated the potential role of chronic local ovarian inflammation in the development of the major subtypes of epithelial ovarian cancer. Factors potentially linked to ovarian inflammation were examined in an Australia\u2010wide case\u2013control study comprising 1,576 women with invasive and low malignant potential (LMP) ovarian tumours and 1,509 population\u2010based controls. We confirmed a statistically significant increase in ovarian cancer risk associated with use of talc in the pelvic region (adjusted odds ratio 1.17, 95% CI: 1.01\u20131.36) that was strongest for the serous and endometrioid subtypes although the latter was not statistically significant (adjusted odds ratios 1.21, 95% CI 1.03\u20131.44 and 1.18, 95% CI 0.81\u20131.70, respectively). Other factors potentially associated with ovarian inflammation (pelvic inflammatory disease, human papilloma virus infection and mumps) were not associated with risk but, like others, we found an increased risk of endometrioid and clear cell ovarian cancer only among women with a history of endometriosis. Regular use of aspirin and other nonsteroidal anti\u2010inflammatory drugs was inversely associated with risk of LMP mucinous ovarian tumours only. We conclude that on balance chronic inflammation does not play a major role in the development of ovarian cancer. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23017","type":"journal-article","created":{"date-parts":[[2007,8,25]],"date-time":"2007-08-25T03:17:02Z","timestamp":1188011822000},"page":"170-176","source":"Crossref","is-referenced-by-count":200,"title":["Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer"],"prefix":"10.1002","volume":"122","author":[{"given":"Melissa A.","family":"Merritt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le C.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Nagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Australian Cancer Study (Ovarian Cancer) and Australian Ovarian Cancer Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.17.1459"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2005.12.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<351::AID-IJC7>3.0.CO;2-M"},{"key":"e_1_2_6_6_2","first-page":"1955","article-title":"Perineal application of cosmetic talc and risk of invasive epithelial ovarian cancer: a meta\u2010analysis of 11,933 subjects from sixteen observational studies","volume":"23","author":"Huncharek M","year":"2003","journal-title":"Anticancer Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009128"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.249"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200003000-00006"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000257126.68803.03"},{"key":"e_1_2_6_11_2","first-page":"19","article-title":"Perineal exposure to talc and ovarian cancer risk","volume":"80","author":"Harlow BL","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287397609529432"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk057"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970615)79:12<2396::AID-CNCR15>3.0.CO;2-M"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20434"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.09.014"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-9351(86)80100-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70597-5"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.4.324"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)90135-X"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.01846.x"},{"key":"e_1_2_6_22_2","first-page":"667","article-title":"Pelvic inflammatory disease and risk of ovarian cancer","volume":"5","author":"Parazzini F","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_23_2","first-page":"3670","article-title":"Population\u2010based case\u2010control study of ovarian cancer in Shanghai","volume":"49","author":"Shu XO","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_6_24_2","first-page":"447","article-title":"Pelvic inflammatory disease and the risk of epithelial ovarian cancer","volume":"4","author":"Risch HA","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_25_2","first-page":"825","article-title":"Genital herpes. 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