{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:07Z","timestamp":1786977847161,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T00:00:00Z","timestamp":1188172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a recent study, prostatectomy specimens from which\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    was cultured were more likely to have inflammation than culture\u2010negative specimens or specimens positive for other bacteria, leading the authors to hypothesize that\n                    <jats:italic>P. acnes<\/jats:italic>\n                    \u2010mediated inflammation may contribute to prostate carcinogenesis. To indirectly explore associations between\n                    <jats:italic>P. acnes<\/jats:italic>\n                    and prostate cancer, we investigated severe acne, as measured by tetracycline use for 4 or more years, in relation to incident prostate cancer in the Health Professionals Follow\u2010up Study. On the 1992 follow\u2010up questionnaire, participants were asked whether they had ever used \u201ctetracycline for at least 2 months at a time (\n                    <jats:italic>e.g.<\/jats:italic>\n                    , for acne or other reason)\u201d and their duration of use. Prostate cancer diagnoses were ascertained on each subsequent biennial questionnaire and confirmed by medical record review. Between 1992 and 2002, 2,147 cases of prostate cancer were reported among 34,629 eligible participants. Men who used tetracycline for 4 or more years had a significantly higher risk of prostate cancer (16 cases, 1,569 person\u2010years) than men who did not use tetracycline (2,071 cases, 304,822 person\u2010years, multivariable\u2010adjusted RR = 1.70, 95% CI: 1.03\u20132.80). Although intriguing, this finding should be viewed cautiously because of the small number of exposed cases, indirect assessment of severe acne, and complex etiology of acne, which is not limited to\n                    <jats:italic>P. acnes<\/jats:italic>\n                    infection. Therefore, additional biologic and epidemiologic studies are necessary to determine and elucidate the possible role of\n                    <jats:italic>P. acnes<\/jats:italic>\n                    infection in prostate carcinogenesis. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.23032","type":"journal-article","created":{"date-parts":[[2007,8,27]],"date-time":"2007-08-27T13:17:29Z","timestamp":1188220649000},"page":"2688-2692","source":"Crossref","is-referenced-by-count":66,"title":["Acne and risk of prostate cancer"],"prefix":"10.1002","volume":"121","author":[{"given":"Siobhan","family":"Sutcliffe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William 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