{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:45:36Z","timestamp":1781909136979,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T00:00:00Z","timestamp":1188518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Cancer Foundation, Swedish Research Council\/Longitudinal Studies"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is few data on the association between dietary fiber intake and estrogen receptor (ER)\/progesterone receptor (PR)\u2010defined breast cancer risk. We evaluated the association between dietary fiber and ER\/PR\u2010defined breast cancer risk stratified by postmenopausal hormone use, alcohol intake, and family history of breast cancer in the population\u2010based Swedish Mammography Screening Cohort comprising 51,823 postmenopausal women. Fiber intake was measured by food\u2010frequency questionnaire collected in 1987 and 1997. Relative risks (RRs) were estimated by hazard ratio derived from Cox proportional hazard regression models. During an average of 8.3\u2010year follow\u2010up, 1,188 breast cancer cases with known ER\/PR status were diagnosed. When comparing the highest to the lowest quintile, we observed non\u2010significant inverse associations between total fiber intake and the risk of all tumor subtypes; the multivariate\u2010adjusted RRs were 0.85 (95% CI: 0.69\u20131.05) for overall, 0.85 (0.64\u20131.13) for ER+PR+, 0.83 (0.52\u20131.31) for ER+PR\u2212 and 0.94 (0.49\u20131.80) for ER\u2212PR\u2212. For specific fiber, we observed statistically significant risk reductions for overall (34%) and for ER+PR+ (38%) for the highest <jats:italic>versus<\/jats:italic> lowest quintile of fruit fiber, and non\u2010significant inverse associations for other subtypes of cancer and types of fiber. Among ever\u2010users of postmenopausal hormone (PMH), total fiber intake and especially cereal fiber were statistically significantly associated with \u223c50% reduced risk for overall and ER+PR+ tumors when comparing the highest to the lowest quartile, but no association was observed among PMH never users. Our results suggest that dietary fiber intake from fruit and cereal may play a role in reducing breast cancer risk. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23060","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T14:46:56Z","timestamp":1188571616000},"page":"403-412","source":"Crossref","is-referenced-by-count":61,"title":["Dietary fiber intake and risk of postmenopausal breast cancer defined by estrogen and progesterone receptor status\u2014A prospective cohort study among Swedish women"],"prefix":"10.1002","volume":"122","author":[{"given":"Reiko","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Rylander\u2010Rudqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehira","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Adlercreutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036102"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1079\/PNS200068"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600890"},{"key":"e_1_2_5_6_2","first-page":"137","volume-title":"Diet and sex hormone metabolism","author":"Adlercreutz H","year":"1991"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212163072502"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635588609513887"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.13.899"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.Supplement_1.S85"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635589009514040"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/54.3.520"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90022-O"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.3.787"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.1.166"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940801)74:3 <1125::AID-CNCR2820741521>3.0.CO;2-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(92)90359-Q"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0016-5085(84)80129-8","article-title":"Does fiber\u2010rich food containing animal lignan precursors protect against both colon and breast cancer? 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