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In addition, the change in phenotype was stable, even after the removal of Epo. Measurement of mono\u2010 and oligonucleosome formation revealed that long\u2010term Epo treated A2780 cells exhibited markedly less apoptosis than nonerythropoietin treated cells at essentially all concentrations of paclitaxel tested. Western blot analyses revealed that the long\u2010term Epo treated cells had significantly reduced expression of apoptosis\u2010related proteins Bcl\u20102 and Bcl\u201010. These findings may have implications for the clinical use of recombinant human Epo and other erythropoiesis stimulating agents to correct anemia in paclitaxel\u2010treated cancer patients. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23071","type":"journal-article","created":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T15:18:49Z","timestamp":1190647129000},"page":"281-288","source":"Crossref","is-referenced-by-count":28,"title":["Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel\u2010resistant 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