{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:55:10Z","timestamp":1791014110260,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T00:00:00Z","timestamp":1190592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epithelial ovarian carcinoma (EOC) spreads by implantation of tumor cells onto the human peritoneal mesothelial cells (HPMCs) lining the peritoneal cavity. The aim of this study was to determine whether the stromal cell\u2010derived factor\u20101\u03b1 (SDF\u20101\u03b1)\/CXCR4 axis is involved in the interaction of EOC cells with HPMCs in peritoneal metastasis. Clinically, we first evaluated CXCR4 expression in sections from 36 primary EOCs using immunohistochemistry. We next examined whether SDF\u20101\u03b1 played roles in EOC progression, including in proliferation, cell motility, attachment to HPMCs, and the <jats:italic>in vivo<\/jats:italic> development of peritoneal metastasis through CXCR4. Of the 36 carcinomas, 16 cases (44.4%) were positive for CXCR4 immunoexpression. Positive CXCR4 expression significantly predicted poorer overall survival compared with negative expression (<jats:italic>p<\/jats:italic> = 0.0069). We found CXCR4 expression in both EOC cells and HPMCs. In contrast, the level of production of SDF\u20101\u03b1 by HPMCs was higher than that by various EOC cells. Functionally, SDF\u20101\u03b1 induced enhanced attachment between ES\u20102 cells and HPMCs or extracellular matrix components. The enhancement of adhesion potential by SDF\u20101\u03b1 was inhibited by AMD3100, a CXCR4 antagonist, and by phosphatidylinositol 3 kinase and p44\/42 inhibitors. Furthermore, intraperitoneal treatment with AMD3100 resulted in reduced dissemination in nude mice inoculated with ES\u20102 cells. The present results suggest that there may be a link between the SDF\u20101\u03b1\/CXCR4 axis and enhanced intraperitoneal dissemination of EOC and that CXCR4 may be a novel target for the treatment of EOC. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23083","type":"journal-article","created":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T15:19:02Z","timestamp":1190647142000},"page":"91-99","source":"Crossref","is-referenced-by-count":183,"title":["Involvement of SDF\u20101\u03b1\/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian 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