{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:41:58Z","timestamp":1791009718272,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although smoking is a major cause of lung cancer, the proportion of lung cancer cases among Japanese women who never smoked is high. As the prevalence of smoking in Japan is relatively high in men but low in women, the development of lung cancer in non\u2010smoking Japanese women may be significantly impacted by passive smoking. We conducted a population\u2010based prospective study established in 1990 for Cohort I and in 1993 for Cohort II. The study population was defined as all residents aged 40\u201369 years at the baseline survey. 28,414 lifelong non\u2010smoking women provided baseline information on exposure to tobacco smoke from their husband, at the workplace and during childhood. Over 13 years of follow\u2010up, 109 women were newly diagnosed with lung cancer, of whom 82 developed adenocarcinoma. Compared with women married to never smokers, hazard ratio (HR) [95% confidence interval (CI)] for all lung cancer incidence in women who lived with a smoking husband was 1.34 (95% CI 0.81\u20132.21). An association was clearly identified for adenocarcinoma (HR 2.03, 95% CI 1.07\u20133.86), for which dose\u2010response relationships were seen for both the intensity (<jats:italic>p<\/jats:italic> for trend = 0.02) and amount (<jats:italic>p<\/jats:italic> for trend = 0.03) of the husband's smoking. Passive smoking at the workplace also increased the risk of lung cancer (HR 1.32, 95% CI 0.85\u20132.04). Moreover, a higher risk of adenocarcinoma was seen for combined husband and workplace exposure (HR 1.93, 95% CI 0.88\u20134.23). These findings confirm that passive smoking is a risk factor for lung cancer, especially for adenocarcinoma among Japanese women. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23116","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T15:16:48Z","timestamp":1192202208000},"page":"653-657","source":"Crossref","is-referenced-by-count":80,"title":["Passive smoking and lung cancer in Japanese non\u2010smoking women: A prospective study"],"prefix":"10.1002","volume":"122","author":[{"given":"Norie","family":"Kurahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Sasazuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomotaka","family":"Sobue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Tsugane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the JPHC Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,26]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"22","volume-title":"Mortality statistics from malignant neoplasms, Special Report of Vital Statistics in Japan","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.8015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_6_5_2","first-page":"595","article-title":"Comparison of clinico\u2010epidemiological features of lung cancer patients with and without a history of smoking","volume":"14","author":"Shimizu H","year":"1984","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_6_6_2","first-page":"200","volume-title":"The National Health and Nutrition Survey in Japan, 2004","year":"2004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311183292105"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90960-1"},{"key":"e_1_2_6_9_2","volume-title":"IARC Monographs on the evaluation of carcinogenic risks to humans","author":"International Agency for Research on Cancer","year":"2004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7114.980"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-7435(84)80017-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018483121625"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.824"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012273806199"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7398.1057"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38327.648472.82"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38834.522894.2F"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840301)53:5<1214::AID-CNCR2820530532>3.0.CO;2-8"},{"key":"e_1_2_6_19_2","first-page":"4804","article-title":"Passive smoking and lung cancer among Japanese women","volume":"46","author":"Akiba S","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_6_20_2","first-page":"389","article-title":"A case\u2010control study of lung cancer in nonsmoking women. 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