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Immunofluorescence microscopy and ultrastructural analysis revealed the localization of hPARM\u20101 to Golgi, plasma membrane and the early endocytic pathway but not in lysosomes. Biochemical and deglycosylation studies showed hPARM\u20101 as a highly glycosylated, mucin\u2010like type I transmembrane protein. Analysis of expression of hPARM\u20101 in various human tissues revealed its presence in most human tissues with especially high expression in heart, kidney and placenta. Androgen controls the expression of the gene as a marked 7\u2010fold increase is seen in the androgen\u2010dependent prostate cancer cell line, LNCaP on androgen stimulation. This is further supported by its decrease in expression in CWR22 xenograft upon castration. Moreover, ectopic expression of hPARM\u20101 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation. These results suggest that hPARM\u20101 may have a role in normal biology of the prostate cell and in prostate cancer. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23185","type":"journal-article","created":{"date-parts":[[2007,11,20]],"date-time":"2007-11-20T23:17:20Z","timestamp":1195600640000},"page":"1229-1235","source":"Crossref","is-referenced-by-count":24,"title":["Human PARM\u20101 is a novel mucin\u2010like, androgen\u2010regulated gene exhibiting proliferative effects in prostate cancer cells"],"prefix":"10.1002","volume":"122","author":[{"given":"Cathrine","family":"Fladeby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailly N.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Barois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petri 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