{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:08:37Z","timestamp":1785557317187,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T00:00:00Z","timestamp":1193097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The results of prospective studies that have examined the association between serum cholesterol levels and the incidence of gastric cancer remain controversial. To examine this issue in a general population, a total of 2,604 subjects aged 40 years or older were followed up prospectively for 14 years. During the follow\u2010up period, gastric cancer developed in 97 subjects. The age\u2010 and sex\u2010adjusted incidence of gastric cancer by quartiles of serum cholesterol level, namely, &lt;4.06, 4.06\u20135.32, 5.33\u20136.04 and \u22656.05 mmol\/L, were 3.9, 3.3, 3.1 and 2.1 per 1,000 person\u2013years, respectively. The risk of gastric cancer increased with decreasing cholesterol level (age\u2010 and sex\u2010adjusted hazard ratio [HR], 1.22; 95% confidence interval [CI], 1.01\u20131.49;<jats:italic>p<\/jats:italic>= 0.04 for a decrease of 1 mmol\/L in serum cholesterol level). This inverse association remained unchanged even after adjustment for other confounding factors, namely,<jats:italic>Helicobacter pylori<\/jats:italic>infection, atrophic gastritis, family history of malignant neoplasm, smoking habits, body mass index, hemoglobin A1c, white blood cell count and dietary factors (adjusted HR, 1.28; 95% CI, 1.03\u20131.58;<jats:italic>p<\/jats:italic>= 0.02). This association was significant for intestinal\u2010type gastric cancers, but not for diffuse\u2010type. As regards cancer stage, the inverse cholesterol\u2010cancer association was marginally significant for early gastric cancer after multivariate\u2010adjustment (adjusted HR, 1.25; 95% CI, 0.97\u20131.61;<jats:italic>p<\/jats:italic>= 0.09), but was not for advanced gastric cancer probably due to the small number of cases. In conclusion, our findings suggest that low serum cholesterol levels are an independent risk factor for developing gastric cancer, especially intestinal\u2010type gastric cancer. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23191","type":"journal-article","created":{"date-parts":[[2007,10,23]],"date-time":"2007-10-23T19:16:31Z","timestamp":1193166991000},"page":"909-914","source":"Crossref","is-referenced-by-count":63,"title":["Impact of serum total cholesterol on the incidence of gastric cancer in a population\u2010based prospective study: The Hisayama 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