{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:17:11Z","timestamp":1791037031711,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T00:00:00Z","timestamp":1193788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the impact of a family history of breast\/ovarian cancer on the risk of secondary leukemia following breast cancer. At the Geneva cancer registry, we identified 4,397 patients diagnosed with invasive breast cancer between 1990 and 2004. Patients were followed up for leukemia until the end of 2005. Family history was categorized as positive in patients with \u22651 first\u2010 or second\u2010degree relative with breast\/ovarian cancer. We compared leukemia rates in patients with positive and negative family histories with those expected in the general population, generating standardized incidence ratios (SIRs). With Cox regression analysis, we calculated adjusted risks of secondary leukemia in patients with familial risks compared to those without it. Breast cancer patients had a significantly increased risk of secondary acute leukemia (SIR 3.2, 95% CI: 1.2\u20136.9) but not of chronic leukemia (SIR 1.6, 95% CI: 0.6\u20133.5). Among patients with a positive family history (<jats:italic>n<\/jats:italic> = 1.125, 25.6%), the SIRs were 5.7 (95% CI: 1.2\u201316.6) for acute and 5.2 (95% CI: 1.4\u201313.3) for chronic leukemia. Among breast cancer patients, family history was independently associated with leukemia [adjusted hazard ratio (HR<jats:sub>adj<\/jats:sub>) of 3.2, 95% CI: 1.1\u20139.2, among patient with <jats:italic>vs<\/jats:italic>. without family history]. The effect of family history was stronger for chronic leukemia (HR<jats:sub>adj<\/jats:sub>: 11.6, 95% CI 1.3\u2013104.7) than for acute leukemia (HR<jats:sub>adj<\/jats:sub> 1.6, 95% CI: 0.4\u20136.6). Breast cancer patients with a family history of breast\/ovarian have an increased risk of secondary leukemia, both compared to the general population as well as to breast cancer patients without family histories. This excess risk is largely due to the increased risk of secondary chronic leukemia. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23212","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T17:18:14Z","timestamp":1193851094000},"page":"1114-1117","source":"Crossref","is-referenced-by-count":13,"title":["Family history of breast or ovarian cancer modifies the risk of secondary leukemia after breast cancer: Results from a population\u2010based study"],"prefix":"10.1002","volume":"122","author":[{"given":"Helena M.","family":"Verkooijen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Fioretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Rapiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Vlastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Neyroud\u2010Caspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre O.","family":"Chappuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bouchardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9460-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2005.11.007"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199206253262605"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006489918700"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.114"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.15.2836"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03000.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.01.013"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403727"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.001.0001"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02111.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705213162101"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf075"},{"key":"e_1_2_6_15_2","first-page":"666","volume-title":"Cancer incidence in five continents","author":"Bouchardy C","year":"1997"},{"key":"e_1_2_6_16_2","volume-title":"ICD\u2010O International classification of diseases for oncology","author":"World Health Organization (WHO)","year":"1976"},{"key":"e_1_2_6_17_2","first-page":"165","article-title":"Occurrence and impact of genetic factors in breast cancer among the female population in Geneva: creation of the Geneva familial breast cancer registry","volume":"2650","author":"Bouchardy C","year":"2002","journal-title":"Bull Suisse Cancer"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.010918"},{"key":"e_1_2_6_19_2","volume-title":"TNM classification of malignant tumours","author":"Sobin LH","year":"2002"},{"key":"e_1_2_6_20_2","volume-title":"Person\u2010Years (PYRS). A Fortran program for cohort study analysis","author":"Coleman MP","year":"1989"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602914"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-5022"},{"key":"e_1_2_6_23_2","first-page":"289","article-title":"Is family history of breast cancer a marker of susceptibility to exposures in the incidence of de novo adult acute leukemia?","volume":"12","author":"Rauscher GH","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.23212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.23212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T07:30:56Z","timestamp":1697182256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.23212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,24]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/ijc.23212"],"URL":"https:\/\/doi.org\/10.1002\/ijc.23212","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,24]]}}}