{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:58:32Z","timestamp":1781873912124,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T00:00:00Z","timestamp":1197417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a population\u2010based case\u2010control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in\u2010person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (\u2265160 mg\/dl) had a 1.4\u2010fold risk of biliary stones (95% CI = 1.1\u20131.9), a 1.9\u2010fold risk of gallbladder cancer (95% CI = 1.3\u20132.8), and a 4.8\u2010fold risk of bile duct cancer (95% CI = 2.8\u20138.1), compared to the reference group (third quintile: 90\u2013124 mg\/dl). Participants in the lowest quintile of high\u2010density lipoprotein (HDL) (&lt;30 mg\/dl) had a 4.2\u2010fold risk of biliary stones (95% CI = 3.0\u20136.0), an 11.6\u2010fold risk of gallbladder cancer (95% CI = 7.3\u201318.5), and a 16.8\u2010fold risk of bile duct cancer (95% CI = 9.1\u201330.9), relative to the reference group (third quintile: 40\u201349 mg\/dl). In addition, total cholesterol, low\u2010density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23307","type":"journal-article","created":{"date-parts":[[2007,12,12]],"date-time":"2007-12-12T18:17:53Z","timestamp":1197483473000},"page":"2322-2329","source":"Crossref","is-referenced-by-count":88,"title":["Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population\u2010based study in China"],"prefix":"10.1002","volume":"122","author":[{"given":"Gabriella","family":"Andreotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Chen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing\u2010Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Quan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai\u2010He","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim N.","family":"Danforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Althuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann W.","family":"Hsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980130)75:3<368::AID-IJC7>3.0.CO;2-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195149616.003.0040"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604047"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411807"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90978-A"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260401"},{"key":"e_1_2_6_8_2","first-page":"253","article-title":"Lipids in biliary lithogenesis","volume":"47","author":"Singh V","year":"1997","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70045-5"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22375"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22756"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/clinchem\/25.3.439","article-title":"Automated measurement of total cholesterol and triglycerides, in \u201ctandem,\u201d on the discrete sample analyzer. 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