{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:07:40Z","timestamp":1775279260591,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T00:00:00Z","timestamp":1200268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the associations of breast cancer risk with polymorphisms in the <jats:italic>XPC<\/jats:italic> and <jats:italic>XPD\/ERCC2<\/jats:italic> DNA nucleotide excision repair genes, a case\u2010control study nested within a prospective cohort of 14,274 women was conducted. Genotypes were characterized for 612 incident, invasive breast cancer cases and their 1:1 matched controls. The homozygous variant of a poly(AT) insertion\/deletion polymorphism in intron 9 of the <jats:italic>XPC<\/jats:italic> gene (<jats:italic>XPC<\/jats:italic>\u2010PAT+\/+), was associated with breast cancer risk [odds ratio (OR) = 1.45, 95% confidence interval: 1.07\u20131.97], after adjustment for other breast cancer risk factors. The breast cancer risk associated with <jats:italic>XPC<\/jats:italic>\u2010PAT+\/+ did not differ by age at diagnosis. There was an indication of an interaction (<jats:italic>p<\/jats:italic> = 0.08) between the <jats:italic>XPC<\/jats:italic>\u2010PAT+\/+ genotype and cigarette smoking. Ever smokers with the <jats:italic>XPC<\/jats:italic>\u2010PAT+\/+ genotype were at elevated risk of breast cancer (OR = 1.56, CI: 0.95\u20132.58), but no differences were observed among never smokers. Analyses of the <jats:italic>ERCC2<\/jats:italic> Lys751Gln polymorphism did not show an association with breast cancer risk, either overall or at younger ages. The results suggest that breast cancer risk is related to the <jats:italic>XPC<\/jats:italic> haplotype tagged by the <jats:italic>XPC<\/jats:italic>\u2010PAT+\/+ insertion\u2010deletion polymorphism in intron 9. Further study of the <jats:italic>XPC<\/jats:italic> haplotypes and their interactions with smoking in relation to breast cancer risk is needed. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23361","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T18:48:09Z","timestamp":1200336489000},"page":"2101-2105","source":"Crossref","is-referenced-by-count":26,"title":["Polymorphisms in <i>XPC<\/i> and <i>ERCC2<\/i> genes, smoking and breast cancer risk"],"prefix":"10.1002","volume":"122","author":[{"given":"Roy 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