{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T17:12:29Z","timestamp":1722618749007},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T00:00:00Z","timestamp":1207180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously showed that mice carrying an activated <jats:italic>Cdk4<\/jats:italic> mutation together with melanocyte\u2010specific mutant Hras (<jats:italic>Cdk4<jats:sup>R24C\/R24C<\/jats:sup>\/TPras<\/jats:italic>) develop melanoma spontaneously, but penetrance is increased and age of onset reduced after neonatal ultraviolet radiation (UVR) exposure. UVR\u2010treated mice were more likely to develop multiple primary lesions, and these melanomas more often expressed Trp53, and less often expressed c\u2010Myc, than melanomas from nonirradiated mice (Hacker <jats:italic>et al<\/jats:italic>., Cancer Res 2006;66:2946\u201352). These data suggest differences in mechanisms of tumorigenesis between melanomas developing spontaneously, or as a result of UVR exposure. To further delineate these differences, we compared global gene expression between spontaneous and UVR\u2010induced melanomas from these mice using microarrays. We found 264 genes differentially expressed between these groups (ANOVA, <jats:italic>p<\/jats:italic> &lt; 0.05). Selected candidate genes were validated using qRT\u2010PCR, which confirmed upregulation of <jats:italic>Gpr155<\/jats:italic> and <jats:italic>Bmp7<\/jats:italic>, and downregulation of <jats:italic>Plagl1<\/jats:italic>, <jats:italic>Akap12<\/jats:italic> and <jats:italic>Il18<\/jats:italic> in UVR\u2010induced mouse melanomas. In humans, epidemiological studies suggest that there may be 2 predominant pathways to melanoma development. One characterized by chronic UVR exposure and which leads mainly to melanomas on sun\u2010exposed sites; the other associated with low UVR exposure and leading predominantly to melanomas on less\u2010exposed body sites. We found by immunohistochemical analysis that, comparing a series of human melanomas from the head (a chronically sun\u2010exposed site; <jats:italic>N<\/jats:italic> = 82) with a set from the trunk (an intermittently exposed site; <jats:italic>N<\/jats:italic> = 65), the prevalence of IL\u201018 expression was significantly lower in melanomas on the head (16%) than on truncal melanomas (34%, <jats:italic>p<\/jats:italic> = 0.011). We conclude that loss of <jats:italic>IL\u201018<\/jats:italic> is a marker of UVR\u2010induced melanoma, both in animal models and humans. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23389","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T22:17:44Z","timestamp":1207261064000},"page":"227-231","source":"Crossref","is-referenced-by-count":14,"title":["Reduced expression of IL\u201018 is a marker of ultraviolet radiation\u2010induced melanomas"],"prefix":"10.1002","volume":"123","author":[{"given":"Elke","family":"Hacker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Whiteman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Pavey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15649-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2006.05.008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.806"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<843::AID-IJC8>3.0.CO;2-U"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.1325"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg123"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3196"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207563"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9013-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2006.08.004"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.08.008"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.02.020"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01370.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.5.2896"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb717"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0003"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01866.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2006.133"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301519"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357900009031825"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2503"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0121"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2984"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.23389","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.23389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:50:31Z","timestamp":1695912631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.23389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1002\/ijc.23389"],"URL":"https:\/\/doi.org\/10.1002\/ijc.23389","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,24]]}}}