{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:03:43Z","timestamp":1791180223531,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T00:00:00Z","timestamp":1202774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association between hepatitis C virus (HCV) infection and risk of malignant lymphoma remains controversial, perhaps due to small\u2010sized studies and low prevalence of HCV in the general population. On the basis of a large Danish\u2010Swedish population\u2010based case\u2010control study, 2,819 lymphoma patients and 1,856 controls of second\u2010generation Danish\u2010Swedish origin were screened for HCV infection using an enzyme\u2010linked immunosorbent assay and a confirming recombinant immunoblot assay (RIBA) test. Positive samples were tested with real\u2010time PCR for the presence of HCV RNA. The association between HCV infection and risk of malignant lymphoma was assessed by logistic regression. When intermediate RIBA test results were interpreted as positive, anti\u2010HCV antibody positivity was associated with a nonsignificant increased risk of non\u2010Hodgkin lymphoma (NHL) overall (odds ratio (OR) = 2.2; 95% confidence interval (CI) 0.9\u20135.3;\n                    <jats:italic>n<\/jats:italic>\n                    = 20 cases), of B\u2010cell lymphomas combined (OR = 2.4 [1.0\u20135.8];\n                    <jats:italic>n<\/jats:italic>\n                    = 20) and of lymphoplasmacytic lymphoma (OR = 5.2 [1.0\u201326.4];\n                    <jats:italic>n<\/jats:italic>\n                    = 2). No patients with T\u2010cell or Hodgkin lymphoma were HCV\u2010positive. A more conservative definition of HCV positivity (disregarding intermediate RIBA results) resulted in an OR = 1.6 (0.3\u20138.5;\n                    <jats:italic>n<\/jats:italic>\n                    = 5) for NHL overall. When the definition was further restricted to require HCV RNA positivity, OR was 1.7 (0.2\u201316.2;\n                    <jats:italic>n<\/jats:italic>\n                    = 3) for NHL overall. Our findings from a population with a low prevalence of HCV suggest a positive association between HCV and risk of NHL, in particular of B\u2010cell origin. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ijc.23416","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T13:47:45Z","timestamp":1202824065000},"page":"1885-1890","source":"Crossref","is-referenced-by-count":60,"title":["Hepatitis C infection and risk of malignant lymphoma"],"prefix":"10.1002","volume":"122","author":[{"given":"Claudia","family":"Sch\u00f6llkopf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin 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