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Female residents (age \u2265 30 years) of Taoyuan, Taiwan were invited. After signing informed consent, every participant had a Pap smear and a HPV testing. Patients with Pap \u2265 atypical squamous cell of undetermined significance (Group I) or those with HPV\u2010positive but normal cytology (Group II) were referred for a colposcopic examination. A total of 10,014 women were eligible. The overall HPV prevalence was 10.8% (95% confidence interval 10.5%\u201311.4%) in the study population. A total of 37 types of HPV were identified and the leading three were HPV\u201052, \u201018 and \u201058. There was a significant positive correlation of HPV prevalence with older age, postmenopausal status, current\u2010user of oral contraceptives and never\u2010user of hormone replacement therapy. Past users of oral contraceptives and never users of Pap were associated with higher risk of abnormal Pap, while age 40\u201349 strata had lower risk. Fifty\u2010nine cases of cervical intraepithelial neoplasia (CIN) 2 from Group I and additional 11 from Group II were identified. The improvement of sensitivity with additional HPV testing was 15.3%. Besides, no specific subgroup was found to most benefit from the combined strategy. The value of adding HPV test to conventional Pap smear has to be evaluated after longer\u2010term follow\u2010up of this population\u2010based cohort. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23441","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T17:19:01Z","timestamp":1205428741000},"page":"2835-2841","source":"Crossref","is-referenced-by-count":22,"title":["Cervical cancer screening program integrating Pap smear and HPV DNA testing: A population\u2010based study"],"prefix":"10.1002","volume":"122","author":[{"given":"Angel","family":"Chao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang\u2010Hung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyong\u2010Huey","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huei\u2010Jean","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swei","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheue\u2010Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Ming","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang\u2010Yu","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Lang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu\u2010Chun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Erh","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Chang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_2_6_3_2","unstructured":"Department of Health Executive Yuan Health Statistics in Taiwan 2005.http:\/\/www.doh.gov.tw\/EN2006\/DM\/DM2_p01.aspx?class_no=390&now_fod_list_no=9291&level_no=3&doc_no=52235."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00009"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji162"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91086-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1749"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.10.818"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/373901"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600918"},{"key":"e_1_2_6_12_2","first-page":"905","article-title":"Clinical management guidelines for obstetrician\u2013gynecologists, number 61, April 2005. 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