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The adverse cytogenetic abnormalities gain of 1q21, deletion 17p13 and deletion 13q14 significantly correlated with at least one DCE\u2010MRI finding (aberrant \u201cfocal\u201d microcirculation pattern, increase in median microcirculation parameter Amplitude <jats:italic>A<\/jats:italic> or exchange rate constant <jats:italic>kep<\/jats:italic>). We conclude that gain of 1q21, deletion 13q14 and deletion 17p13 trigger the angiogenic cascade in MM. Our findings will have important implications for the design, analysis and stratification for clinical studies of patients with MM in particular if compounds with antiangiogenic activity are used. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23455","type":"journal-article","created":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T14:58:03Z","timestamp":1205938683000},"page":"2871-2875","source":"Crossref","is-referenced-by-count":19,"title":["Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma"],"prefix":"10.1002","volume":"122","author":[{"given":"Jens","family":"Hillengass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian 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