{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:26:54Z","timestamp":1773415614796,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T00:00:00Z","timestamp":1205884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human leukocyte antigens (HLAs) present foreign antigens to the immune system and may be important determinants of cervical neoplasia. Previously published associations between HLA and cervical neoplasia exhibit considerable variation in findings. The biomarkers of cervical cancer risk (BCCR) case\u2010control study addressed the role of specific HLA alleles as cofactors in the development of high\u2010grade cervical intraepithelial neoplasia (HG\u2010CIN) based on the most consistent evidence from published literature. Cases (<jats:italic>N<\/jats:italic> = 381) were women with histologically\u2010confirmed HG\u2010CIN attending colposcopy clinics and controls (<jats:italic>N<\/jats:italic> = 884) were women from outpatient clinics with normal cytological screening smears. Subjects were mainly of French\u2010Canadian descent. Cervical specimens were tested for human papillomavirus (HPV) DNA and HLA genotypes by PGMY L1 consensus primer PCR and a PCR sequence\u2010specific primer method, respectively. Unlike other studies, the DQB1*03 and DRB1*13 allele groups were not associated with risk of HG\u2010CIN. The B7\u2010DRB1*1501\u2010DQB1*0602 haplotype was associated with a 41% overall reduction in HG\u2010CIN risk (odds ratio [OR] = 0.59; 95% confidence interval [CI]: 0.36\u20130.96), and an 83% reduction in risk of HG\u2010CIN among HPV 16 or HPV 18\u2010positive subjects (OR = 0.17; 95%CI: 0.05\u20130.54). Paradoxically, however, the same haplotype was associated with HPV 16\/18 infection risk among controls (OR = 8.44, 95%CI: 1.12\u201363.73). In conclusion, the B7\u2010DRB1*1501\u2010DQB1*0602 haplotype was protective against HG\u2010CIN, especially in individuals infected with oncogenic HPV, but the mechanism of the association seems to involve multiple steps in the natural history of HPV and CIN. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23459","type":"journal-article","created":{"date-parts":[[2008,3,19]],"date-time":"2008-03-19T10:58:15Z","timestamp":1205924295000},"page":"2820-2826","source":"Crossref","is-referenced-by-count":33,"title":["Selected class I and class II HLA alleles and haplotypes and risk of high\u2010grade cervical intraepithelial neoplasia"],"prefix":"10.1002","volume":"122","author":[{"given":"Steven","family":"Ades","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Koushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Duarte\u2010Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Arseneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Gotlieb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Ferenczy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Coutl\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Roger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Biomarkers of Cervical Cancer Risk (BCCR) Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,9]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Globocan 2002: Cancer incidence, mortality and prevalence worldwide","author":"Ferlay J","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_6_5_2","series-title":"IARC monographs on the evaluation of carcinogenic risks to humans","author":"IARC Working Group","year":"1995"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/320696"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003476"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1054\/bjoc.1999.1103","article-title":"Association between high\u2010risk HPV types. 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