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Birth weight is the most frequently studied perinatal factor in relation to risk of childhood cancers, and results have been inconsistent. We investigated whether the risk of CNS tumors and lymphomas in children was associated with three measures of the appropriateness of intra\u2010uterine growth: proportion of optimal birth weight (POBW), birth length (POBL) and weight for length (POWFL). A cohort of 576,633 infants born in Western Australia in 1980\u20132004 were followed from birth to diagnosis of a CNS tumor (<jats:italic>n<\/jats:italic> = 183) or lymphoma (<jats:italic>n<\/jats:italic> = 84) before age 15, death, or December 31, 2005, and analyzed with Cox regression. Overall, there was little evidence of any association between fetal growth and risk of CNS tumors, although risk of ependymoma\/choroid plexus tumors was positively associated with POBL and negatively associated with POWFL. The risk of Hodgkin and Burkitt lymphoma increased with increasing fetal growth among boys only, whereas the increased risk observed with non\u2010Hodgkin lymphoma was only in girls. These associations between fetal growth and disease risk were also observed among children not classified as high birth weight, suggesting that accelerated growth is more important than birth weight <jats:italic>per se<\/jats:italic>. Results were similar when cases were compared with their unaffected siblings, suggesting that the increased growth associated with cancer risk was not general to the family. The associations we observed are consistent with causal pathways involving fetal growth factors. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23486","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T22:13:19Z","timestamp":1208297599000},"page":"436-443","source":"Crossref","is-referenced-by-count":25,"title":["Fetal growth and the risk of childhood CNS tumors and lymphomas in Western Australia"],"prefix":"10.1002","volume":"123","author":[{"given":"Elizabeth","family":"Milne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal L.","family":"Laurvick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"de Klerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian K.","family":"Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Bower","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh287"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg210"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601384"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20159"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-005-0356-9"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603173"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1158\/1055-9965.1057.13.6","article-title":"Birth weight and other risk factors for acute leukemia in the Jerusalem Perinatal Study cohort","volume":"13","author":"Paltiel O","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Preview"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00731.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9011-y"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.4.631"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880019409141806"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70091-X"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690609"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960315)65:6<774::AID-IJC11>3.0.CO;2-4"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0011"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051889"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/1043-2760(91)90003-6"},{"key":"e_1_2_6_19_2","first-page":"81","article-title":"Diverse roles of insulin\u2010like growth factors in pediatric solid tumors","volume":"8","author":"Hirschfeld S","year":"1994","journal-title":"In Vivo"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041490216"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500210"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.5.1713"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90531-G"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60704-9"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1387"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000735"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02778073"},{"key":"e_1_2_6_28_2","first-page":"352","article-title":"IGF. 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