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The aim of this work was to systematically review and summarize estimates of the association between <jats:italic>H. pylori<\/jats:italic> infection and CAG according to the various definitions of CAG. Articles on the association between <jats:italic>H. pylori<\/jats:italic> infection and CAG published until July 2007 were identified. Separate meta\u2010analyses were carried out for studies defining CAG based on gastroscopy with biopsy, serum pepsinogen I (PG I) only, the pepsinogen I\/pepsinogen II ratio (PG I\/PG II ratio) only, or a combination of PG I and the PG I\/PG II ratio. Numbers of identified studies and summary odds ratios (OR) (95% confidence intervals) were as follows: gastroscopy with biopsy: <jats:italic>n<\/jats:italic> = 34, OR = 6.4 (4.0\u201310.1); PG I only: <jats:italic>n<\/jats:italic> = 13, OR = 0.9 (0.7\u20131.2); PG I\/PG II ratio: <jats:italic>n<\/jats:italic> = 8, OR = 7.2 (3.1\u201316.8); combination of PG I and the PG I\/PG II ratio: <jats:italic>n<\/jats:italic> = 20, OR = 5.7 (4.4\u20137.5). Studies with CAG definitions based on gastroscopy with biopsy or the PG I\/PG II ratio (alone or in combination with PG I) yield similarly strong associations of <jats:italic>H. pylori<\/jats:italic> with CAG. The association is missed entirely in studies where CAG is defined by PG I only. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23539","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T16:16:31Z","timestamp":1210954591000},"page":"874-881","source":"Crossref","is-referenced-by-count":48,"title":["Association of <i>Helicobacter pylori<\/i> infection with chronic atrophic gastritis: Meta\u2010analyses according to type of disease definition"],"prefix":"10.1002","volume":"123","author":[{"given":"Melanie N.","family":"Weck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,12]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"4737","article-title":"Gastric precancerous process in a high risk population: cohort follow\u2010up","volume":"50","author":"Correa P","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_5_3_2","volume-title":"GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide IARC cancerbase No 5 version 2.0","author":"Ferlay J","year":"2004"},{"key":"e_1_2_5_4_2","first-page":"959","article-title":"Helicobacter pylori infection is the major risk factor for atrophic gastritis","volume":"91","author":"Kawaguchi H","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91084-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90176-7"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02774209"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1258\/0969141041732184"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0931"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1995.tb00391.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(97)85582-5"},{"key":"e_1_2_5_12_2","first-page":"28","article-title":"Role of Helicobacter pylori in the pathogenesis of atrophic gastritis. 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